The Pierson Laboratory is devoted to understanding the pathological mechanisms involved in rare and undiagnosed pediatric neurogenetic disorders. Tyler Mark Pierson, MD, PhD, has extensive experience in the phenotyping and diagnosing of rare neurogenetic disorders using modern genomic technologies. Pierson did a clinical fellowship in the National Institute of Neurological Disorders and Stroke Neurogenetics Branch at National Institutes of Health (NIH) and was a member of the Undiagnosed Diseases Program at the NIH. In addition to directing his laboratory, Pierson is also the director of the Pediatric Neurogenetics and Neuromuscular Clinic of Cedars-Sinai and the pediatric lead of the Cedars-Sinai Center for the Undiagnosed Patient.
The research goal of the Pierson Laboratory is to extend these diagnostic elements by using patient-derived induced pluripotent stem cells to understand the disease mechanisms associated with these rare pediatric neurogenetic disorders and to explore stem cell–based therapies for the delivery of therapeutic drugs, small molecules, and proteins. The Pierson Lab is also involved in confirming neurogenetic diagnoses in known, but rare, neurogenetic disorders, as well as developing research to link rare presentations of neurogenetic disorders with new genes and causes.
The Pierson Laboratory is affiliated with the Cedars-Sinai Center for the Undiagnosed Patient, Board of Governors Regenerative Medicine Institute, Neurology & Neurosurgery Department and Pediatrics Department.