Rutishauser Laboratory

The Rutishauser Laboratory at Cedars-Sinai is investigating the neural mechanisms of learning, memory and decision-making at level of single neurons and networks thereof. We are a systems neuroscience laboratory and use a combination of in-vivo, single-unit electrophysiology in humans, intracranial electrocorticography, eye tracking, electrical stimulation, behavior and computational, and theoretical approaches. We have helped pioneer the technique of human single-neuron recordings and continue to advance the tools, methods and surgical techniques that allow such experiments. The Rutishauser Laboratory has an ongoing close collaboration with scientists at the California Institute of Technology.

Our overarching goal is to capitalize on special neurosurgical situations to advance knowledge of the human nervous system. Our work is only possible because of a close collaboration between quantitative and experimental neuroscientists, neurologists and neurosurgeons — combining science and medicine.

Work in the Rutishauser Lab is made possible by funding provided by the National Science Foundation (Division of Behavior and Cognitive Sciences), the National Institutes of Health (NIH) (National Institute of Mental Health (NIMH), National Institute of Drug Abuse), the NIH Brain Initiative through the National Institute of Neurological Disorders and Stroke, the Brain & Behavior Research Foundation, the McKnight Endowment Fund for Neuroscience and the NIH NIMH Conte Centers for Basic and Translational Mental Health Research.

The Rutishauser Laboratory is affiliated with the Maxine Dunitz Neurosurgical Institute, Neurosurgery Department, Neurology Department and Department of Biomedical Sciences.

Example extracellular recordings from three different brain areas in a patient with implanted electrodes.