Rutishauser Laboratory

The Rutishauser Laboratory at Cedars-Sinai is investigating the neural mechanisms of learning, memory and decision-making. We are a systems neuroscience laboratory and use a combination of in vivo single-unit electrophysiology in humans, intracranial electrocorticography, eye tracking, behavior, and computational and theoretical approaches. We have helped pioneer the technique of human single-neuron recordings and continue to advance the tools, methods and surgical techniques that allow such experiments. Recent work has focused on the neural representation of novelty and familiarity in the human hippocampus, amygdala and basal ganglia; the theta rhythm; investigation of learning abnormalities in movement disorders; and the neural representation of faces and emotions in the amygdala.

We have an ongoing close collaboration with scientists at the California Institute of Technology. Together, our overarching goal is to capitalize on special neurosurgical situations to advance knowledge of the human nervous system. Our work is only possible because of a close collaboration between quantitative and experimental neuroscientists, neurologists and neurosurgeons — combining science and medicine.

The Rutishauser Laboratory is affiliated with the Maxine Dunitz Neurosurgical Institute, Neurosurgery Department, Neurology Department and Department of Biomedical Sciences.

Example extracellular recordings from three different brain areas in a patient with implanted electrodes.
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