Under the direction of Mehrnoosh Saghizadeh Ghiam, PhD, associate professor of Biomedical Sciences at the Cedars-Sinai Board of Governors Regenerative Medicine Institute Eye Program, the Saghizadeh Ghiam Laboratory is focused on identifying specific molecular corneal defects associated with corneal pathological conditions, such as diabetes. The goal of the Saghizadeh Ghiam Lab is to understand the roles of microRNAs in both the differentiated epithelial and stem cells of normal and diabetic corneas as well as their roles in driving peripheral activation of limbal stem cells in normal and diseased corneas.
The laboratory also investigates the major mechanisms of action of nanosized limbal extracellular vesicles (EVs), which are taken up by neighboring cells, in stem cell maintenance and wound repair in cell cultures and in human organ-cultured corneas. In addition, the Saghizadeh Ghiam Lab investigates the therapeutic potential of EVs for treatment of corneal injuries and diabetic abnormalities. The ultimate goal of the lab is to restore stem cell function for future clinical translation.
The Saghizadeh Ghiam Laboratory is affiliated with Cedars-Sinai Board of Governors Regenerative Medicine Institute, Department of Biomedical Sciences and Eye Program.