See a complete PubMed list of publications by Ekihiro Seki, MD, PhD.

Select Key Publications

Seki E, Tsutsui H, Nakano H, Tsuji NM, Hoshino K, Adachi O, Adachi K, Fuatsugi S, Kuida K, Takeuchi O, et al. Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1β. J Immunol. 2001;166(4): 2651-2657.

Seki E, Tsutsui H, Tsuji NM, Hayashi N, Adachi K, Nakano H, Futatsugi-Yumikra S, Takeuchi O, Hoshino K, Akira S, et al. Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice. J Immunol. 2002;169(7):3863-3868.

Seki E, De Minicis S, Österreicher, CH, Kluwe J, Osawa Y, Brenner DA, Schwabe RF. TLR4 enhances TGFβ signaling and hepatic fibrosis. Nature Medicine 2007;13:1324-1332.

Seki E, De Minicis, S, Inokuchi S, Taura K, Miyai K, van Rooijen N, Schwabe RF, Brenner DA. CCR2 promotes hepatic fibrosis in mice. Hepatology 2009; 50(1):185-197.;jsessionid=340E4F0AF9D13AC582FAF20A343C76C8.f04t03

Seki E, De Minicis S, Gwak GY, Kluwe J, Inokuchi S, Bursill CA, Llovet JM, Brenner DA, Schwabe RF. CCR1 and CCR5 promote hepatic fibrosis. J Clin Invest. 2009;119(7):1858-1870.

Inokuchi S, Aoyama T, Miura K, Österreicher CH, Kodama Y, Miyai K, Akira S, Brenner DA, Seki E. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis and carcinogenesis. Proc Natl Acad Sci U S A. 2010:107(2):844-849.

Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H, Olefsky JM, Brenner DA, Seki E. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1β in mice. Gastroenterology 2010;139(1):323-334.e7.   

Aoyama T, Inokuchi S, Brenner DA, Seki E. CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. Hepatology 2010;52(4):1390-1400.

Inokuchi S, Tsukamoto H, Park EJ, Liu Z-X, Brenner DA, Seki E. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcohol Clin Exp Res. 2011;35(8):1509-1158.

Miura K, Ohnishi H, van Rooijen N, Ohnishi H, Seki E. Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. Am J Physiol Gastrointest Liver Physiol. 2012;302 (11): G1310-1321.

Miura K, Ling Yang, van Rooijen N, Brenner DA, Ohnishi H, Seki E. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Hepatology 2013;57(2):577-589.

Yang L, Inokuchi S, Roh YS, Song J, Loomba R, Park EJ, Seki E. Transforming growth factor-β signaling in hepatocytes promotes hepatic fibrosis and carcinogenesis in mice with hepatocyte-specific deletion of TAK1. Gastroenterology 2013;144(5):1042-1054.e4.

Yang L, Roh YS, Song J, Zhang B, Liu C, Loomba R, Seki E. Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice. Hepatology 2014;59(2):483-495.

Liu C, Chen X, Yang L, Kisseleva T, Brenner DA, Seki E. Transcriptional repression of the transforming growth factor β (TGF-β) pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by nuclear factor κB (NF-κB) p50 enhances TGF-β signaling in hepatic stellate cells. J Biol Chem. 2014;289(10):7082-7091.

Inokuchi-Shimizu S, Park EJ, Yang L, Roh YS, Zhang B, Song J, Pimienta M, Taniguchi K, Wu X, Lagakos WS, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky JM, Karin M, Brenner DA, Seki E. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014;124(8):3566-3578.