The Shaw Laboratory is located within the Smidt Heart Institute and is focused on understanding the cell biology of heart arrhythmias and heart failure progression. Members of the lab study how cardiac ion channels are formed and how channels are targeted to specific subdomains of cardiac cell membrane in both healthy and failing heart muscle. Shaw Lab researchers combine a broad spectrum of backgrounds from talented basic scientists to medical students and clinical cardiologists. The lab research includes the mechanisms of RNA translation, cytoskeleton-based delivery of channels, the mechanisms of heart failure progression, and clinical studies of patients with heart failure. This "cell to bedside" approach is designed to develop novel diagnostics and therapeutics for failing hearts.