Publications

See a complete PubMed list of publications by Fayyaz Sutterwala, MD, PhD and Suzanne Cassel, MD.

Selected Key Publications

Ciraci C, Janczy JR, Jain N, Haasken S, Pecli E Silva C, Benjamim CF, Sadler JJ, Olivier AK, Iwakura Y, Shayakhmetov DM, Sutterwala FS, Cassel SL. Immune complexes indirectly suppress the generation of Th17 responses in vivo. PLOS One. 2016;11(3):e0151252. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0151252.

Ulland TK, Ferguson PJ, Sutterwala FS. Evasion of inflammasome activation by microbial pathogens. J Clin Invest. 2015;125(2):469-477. https://www.jci.org/articles/view/75254.

Janczy JR, Ciraci C, Haasken S, Iwakura Y, Olivier AK, Cassel SL, Sutterwala FS. Immune complexes inhibit interleukin-1 secretion and inflammasome activation. J Immunol. 2014;193(10):5190-5198. http://www.jimmunol.org/content/193/10/5190.

Sutterwala FS, Haasken S, Cassel SL. Mechanism of NLRP3 inflammasome activation. Ann N Y Acad Sci. 2014 Jun;1319:82-95. http://onlinelibrary.wiley.com/doi/10.1111/nyas.12458/abstract.

Cassel SL*, Janczy JR, Bing X, Wilson SP, Olivier AK, Otero JE, Iwakura Y, Shayakhmetov DM, Bassuk AG, Abu-Amer Y, Brogden KA, Burns TL, Sutterwala FS*, Ferguson PJ*. Inflammasome-independent IL-1β mediates autoinflammatory disease in Pstpip2-deficient mice. Proc Natl Acad Sci USA. 2014;111(3):1072-1077. http://www.pnas.org/content/111/3/1072.long.

Iyer SS, He Q, Janczy JR, Elliott EI, Zhong Z, Olivier A, Sadler JJ, Knepper-Adrian V, Han R, Qiao L, Eisenbarth SC, Nauseef WM, Cassel SL*, Sutterwala FS*. Mitochondrial cardiolipin regulates Nlrp3 inflammasome activation. Immunity. 2013;39(2):311-323. http://www.cell.com/immunity/abstract/S1074-7613(13)00329-4.

Curtiss ML, Gorman JV, Businga TR, Traver G, Singh M, Meyerholz DK, Kline JN, Murphy AJ, Vanenzuela DM, Colgan JD, Rothman PB, Cassel SL. Tim-1 regulates Th2 responses in an airway hypersensitivity model. Eur J Immunol. 2012;42(3):651-656. http://onlinelibrary.wiley.com/doi/10.1002/eji.201141581/abstract.

Ulland TK, Buchan BW, Ketterer MR, Fernandes-Alnemri T, Meyerholz DK, Apicella MA, Alnemri ES, Jones BD, Nauseef WM, Sutterwala FS. Cutting edge: mutation of Francisella tularensis mviN leads to increased macrophage AIM2 inflammasome activation and a loss of virulence. J Immunol. 2010;185(5):2670-2674. http://www.jimmunol.org/content/185/5/2670.long.

Iyer SS, Pulskens WP, Sadler JJ, Butter LM, Teske GJ, Ulland T, Eisenbarth SC, Florquin S, Flavell RA, Leemans JC, Sutterwala FS. Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc Natl Acad Sci USA. 2009;106:20388-20393. http://www.pnas.org/content/106/48/20388.

Joly S, Ma N, Sadler JJ, Soll DR, Cassel SL, Sutterwala FS. Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome. J Immunol. 2009;183(6):3578-3581. http://www.jimmunol.org/content/183/6/3578.long.

Cassel SL, Eisenbarth SC, Iyer SS, Sadler JJ, Colegio OR, Tephly LA, Carter AB, Rothman PB, Flavell RA, Sutterwala FS. The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci USA. 2008;105:9035-9040. http://www.pnas.org/content/105/26/9035.long.

Eisenbarth SC, Colegio OR, O'Connor W, Sutterwala FS, Flavell RA. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminum adjuvants. Nature. 2008;453(7198):1122-1126. http://www.nature.com/nature/journal/v453/n7198/full/nature06939.html.

Sutterwala FS, Mijares LA, Li L, Ogura Y, Kazmierczak BI, Flavell RA. Immune recognition of Pseudomonas aeruginosa is mediated by the IPAF inflammasome. J Exp Med. 2007;204:3235-3245. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150987/.

Sutterwala FS, Ogura Y, Szczepanik M, Lara-Tejero M, Lichtenberger GS, Grant EP, Bertin J, Coyle AJ, Galán JE, Askenase, Flavell RA. Critical role for NALP3/CIAS1/Cryopyrin in innate PW and adaptive immunity through its regulation of caspase-1. Immunity. 2006;24(3):317-327. http://www.cell.com/immunity/abstract/S1074-7613(06)00140-3.

Ogura Y, Sutterwala FS, Flavell RA. The inflammasome: first line of the immune response to cell stress. Cell. 2006;126(4):659-662. http://www.cell.com/cell/abstract/S0092-8674(06)01012-9.

*Equal contribution