Publications

See a complete PubMed list of publications by Fayyaz Sutterwala, MD, PhD and Suzanne Cassel, MD.

Selected Key Publications

Elliott EI, MillerAN, BanothB, IyerSI, Stotland A, Weiss JP, Gottlieb RA, Sutterwala FS*, Cassel SL*. Cutting edge: mitochondrial assembly of the NLRP3 inflammasome complex is initiated at priming. J Immunol. 2018 May;200(9):3027-3052. http://www.jimmunol.org/content/200/9/3047.

Hornick EE, Banoth B, Miller AM, Zacharias ZR, Jain N, Wilson ME, Gibson-Corley KN, Legge KL, Bishop GA, Sutterwala FS*, Cassel SL*. Nlrp12 mediates adverse neutrophil recruitment during influenza virus infection. J Immunol. 2018 Feb 1;200(3):1188-1197. http://www.jimmunol.org/content/200/3/1188.

Ulland TK, Jain N, Hornick EE, Elliott EI, ClayGC, Sadler JJ, Mills KAM, Janowski AM, Volk APD, WangK, Legge KL, GakharL, BourdiM, Ferguson PJ, WilsonME, Cassel SL*, Sutterwala FS*. Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment. Nat Commun. 2016 Oct 25;7:13180. https://www.nature.com/articles/ncomms13180.

Janowski AM, ColegioOR, Hornick EE, McNiffJM, MartinMD, BadovinacVP, Norian LA, ZhangW, Cassel SL*, Sutterwala FS*. NLRC4 suppresses melanoma tumor progression independently of inflammasome activation. J. Clin Invest. 2016 Oct 3;126(10):3917-3928. https://www.jci.org/articles/view/86953.

Janczy JR, Ciraci C, Haasken S, Iwakura Y, Olivier AK, Cassel SL, Sutterwala FS. Immune complexes inhibit interleukin-1 secretion and inflammasome activation. J Immunol. 2014;193(10):5190-5198. http://www.jimmunol.org/content/193/10/5190.

Sutterwala FS, Haasken S, Cassel SL. Mechanism of NLRP3 inflammasome activation. Ann N Y Acad Sci. 2014 Jun;1319:82-95. http://onlinelibrary.wiley.com/doi/10.1111/nyas.12458.

Cassel SL*, Janczy JR, Bing X, Wilson SP, Olivier AK, Otero JE, Iwakura Y, Shayakhmetov DM, Bassuk AG, Abu-Amer Y, Brogden KA, Burns TL, Sutterwala FS*, Ferguson PJ*. Inflammasome-independent IL-1β mediates autoinflammatory disease in Pstpip2-deficient mice. Proc Natl Acad Sci USA. 2014;111(3):1072-1077. http://www.pnas.org/content/111/3/1072.

Iyer SS, He Q, Janczy JR, Elliott EI, Zhong Z, Olivier A, Sadler JJ, Knepper-Adrian V, Han R, Qiao L, Eisenbarth SC, Nauseef WM, Cassel SL*, Sutterwala FS*. Mitochondrial cardiolipin regulates Nlrp3 inflammasome activation. Immunity. 2013;39(2):311-323. http://www.cell.com/immunity/abstract/S1074-7613(13)00329-4.

Curtiss ML, Gorman JV, Businga TR, Traver G, Singh M, Meyerholz DK, Kline JN, Murphy AJ, Vanenzuela DM, Colgan JD, Rothman PB, Cassel SL. Tim-1 regulates Th2 responses in an airway hypersensitivity model. Eur J Immunol. 2012;42(3):651-656. http://onlinelibrary.wiley.com/doi/10.1002/eji.201141581.

Ulland TK, Buchan BW, Ketterer MR, Fernandes-Alnemri T, Meyerholz DK, Apicella MA, Alnemri ES, Jones BD, Nauseef WM, Sutterwala FS. Cutting edge: mutation of Francisella tularensis mviN leads to increased macrophage AIM2 inflammasome activation and a loss of virulence. J Immunol. 2010;185(5):2670-2674. http://www.jimmunol.org/content/185/5/2670.

Iyer SS, Pulskens WP, Sadler JJ, Butter LM, Teske GJ, Ulland T, Eisenbarth SC, Florquin S, Flavell RA, Leemans JC, Sutterwala FS. Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc Natl Acad Sci USA. 2009;106:20388-20393. http://www.pnas.org/content/106/48/20388.

Joly S, Ma N, Sadler JJ, Soll DR, Cassel SL, Sutterwala FS. Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome. J Immunol. 2009;183(6):3578-3581. http://www.jimmunol.org/content/183/6/3578.

Cassel SL, Eisenbarth SC, Iyer SS, Sadler JJ, Colegio OR, Tephly LA, Carter AB, Rothman PB, Flavell RA, Sutterwala FS. The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci USA. 2008;105:9035-9040. http://www.pnas.org/content/105/26/9035.

Eisenbarth SC, Colegio OR, O’Connor W, Sutterwala FS, Flavell RA. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminum adjuvants. Nature. 2008;453(7198):1122-1126. http://www.nature.com/nature/journal/v453/n7198/full/nature06939.html.

Sutterwala FS, Mijares LA, Li L, Ogura Y, Kazmierczak BI, Flavell RA. Immune recognition of Pseudomonas aeruginosa is mediated by the IPAF inflammasome. J Exp Med. 2007;204:3235-3245. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150987/.

Sutterwala FS, Ogura Y, Szczepanik M, Lara-Tejero M, Lichtenberger GS, Grant EP, Bertin J, Coyle AJ, Galán JE, Askenase, Flavell RA. Critical role for NALP3/CIAS1/Cryopyrin in innate PW and adaptive immunity through its regulation of caspase-1. Immunity. 2006;24(3):317-327. http://www.cell.com/immunity/abstract/S1074-7613(06)00140-3.

*Equal contribution