See a complete PubMed list of publications by Clive Svendsen, PhD.

Selected Key Publications

Vatine G, Al-Ahmad A, Barriga B, Svendsen S, Salim A, Garcia L, Garcia V, Ho R, Yucer N, Qian T, Lim R, Wu J, Thompson L, Spivia W, Chen Z, Van Eyke J, Palecek S, Refetoff S, Shuster E and Svendsen CN. (2017) Modeling psychomotor retardation using iPSCs from MCT8-deficient patients indicates a prominent role for the blood-brain barrier. Cell Stem Cell 20(6): 831-843.

Rushton D, Andres P, Allred P, Baloh R and Svendsen CN. Patients with ALS show highly correlated progression rates in left and right limb muscles. (2017) Neurology 89(2):196-206.

The Huntington’s Disease iPSC Consortium (2017) Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice. Nature Neuroscience 30(5):648-660.

Ho R, Sances S, Gowing G, Amoroso MW, O’Roarke JG, Shabian A, Wichterle H, Baloh RH, Sareen D and Svendsen CN. (2016) ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks. Nature Neuroscience 19(9):1256-67.

Das MM, Avalos P, Suezaki P, Godoy M, Garcia L, Change CD, Vit JP, Shelley B, Gowing G and Svendsen CN. (2016) Human neural progenitors differentiate into astrocytes and protect motor

Sances S, Bruijn LI, Chandran S, Eggan K, Ho R, Klim JR, Livesey MR, Lowry E, Macklis JD, Rushton D, Sadegh C, Sareen D, Wichterle H, Zhang SC, Svendsen CN. Modeling ALS with motor neurons derived from human induced pluripotent stem cells. Nat Neurosci. 2016 Mar 29;16(4):542-553.

Suzuki M, Svendsen CN. Ex vivo gene therapy using human mesenchymal stem cells to deliver growth factors in the skeletal muscle of a familial ALS rat model. Methods Mol Biol. 2016;1382:325-336.

Thomsen GM, Vit JP, Lamb A, Gowing G, Shelest O, Alkaslasi M, Ley EJ, Svendsen CN. Acute traumatic brain injury does not exacerbate amyotrophic lateral sclerosis in the SOD1 (G93A) rat model(1,2,3). eNeuro. 2015;2(3). pii: ENEURO.0059-14.2015.

Mattis VB, Svendsen CN. Modeling Huntington's disease with patient-derived neurons. Brain Res. 2015 Oct 13. pii: S0006-8993(15)00738-6. [Epub ahead of print.]

Straccia M, Garcia-Diaz Barriga G, Sanders P, Bombau G, Carrere J, Mairal PB, Vinh NN, Yung S, Kelly CM, Svendsen CN, et al. Quantitative high-throughput gene expression profiling of human striatal development to screen stem cell-derived medium spiny neurons. Mol Ther Methods Clin Dev. 2015 Sep 16;2:15030.

Levy M, Boulis N, Rao M, Svendsen CN. Regenerative cellular therapies for neurologic diseases. Brain Res. 2016 May 1;1638(Pt A):88-96. [Epub ahead of print.]

Hatada S, Subramanian A, Mandefro B, Ren S, Kim HW, Tang J, Funari V, Baloh RH, Sareen D, Arumugaswami V, Svendsen CN. Low-dose irradiation enhances gene targeting in human pluripotent stem cells. Stem Cells Transl Med. 2015;4(9):998-1010.

Bernau K, Lewis CM, Petelinsek AM, Reagan MS, Niles DJ, Mattis VB, Meyerand ME, Suzuki M, Svendsen CN. In vivo tracking of human neural progenitor cells in the rat brain using magnetic resonance imaging is not enhanced by ferritin expression. Cell Transplant. 2015 Jul 8. [Epub ahead of print.]

Gutierrez J, Lamanna JJ, Grin N, Hurtig CV, Miller JH, Riley J, Urquia L, Avalos P, Svendsen CN, et al. Preclinical validation of multilevel intraparenchymal stem cell therapy in the porcine spinal cord. Neurosurgery. 2015;77(4):604-612.

Tsai Y, Lu B, Bakondi B, Girman S, Sahabian A, Sareen D, Svendsen CN, Wang S. Human iPSC-derived neural progenitors preserve vision in an AMD-like model. Stem Cells. 2015 Aug;33(8):2537-2549.

Mattis VB, Tom C, Akimov S, Saeedian J, Østergaard ME, Southwell AL, Doty CN, Ornelas L, Sahabian A, Lenaeus L, Mandefro B, Sareen D, Arjomand J, Hayden MR, Ross CA, Svendsen CN. HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity. Hum Mol Genet. 2015;24(11):3257-3271.

Kong SY, Park MH, Lee M, Kim JO, Lee HR, Han BW, Svendsen CN, Sung SH, Kim HJ. Kuwanon V inhibits proliferation, promotes cell survival and increases neurogenesis of neural stem cells. PLOS One. 2015;10(2):e0118188.

Lu B, Lin Y, Tsai Y, Girman S, Adamus G, Jones MK, Shelley B, Svendsen CN, Wang S. A subsequent human neural progenitor transplant into the degenerate retina does not compromise initial graft survival or therapeutic efficacy. Transl Vis Sci Technol. 2015;4(1):7.

Lu XH, Mattis VB, Wang N, Al-Ramahi I, van den Berg N, Fratantoni SA, Waldvogel H, Greiner E, Osmand A, Elzein K, Xiao J, Dijkstra S, de Pril R, Vinters HV, Faull R, Signer E, Kwak S, Marugan JJ, Botas J, Fischer DF, Svendsen CN, et al. Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease. Sci Transl Med. 2014;6(268):268ra178.

Das MM, Svendsen CN. Astrocytes show reduced support of motor neurons with aging that is accelerated in a rodent model of ALS. Neurobiol Aging. 2015;36(2):1130-1139.

Thomsen GM, Gowing, Latter J, Chen M, Vit JP, Staggenborg K, Avalos P, Alkaslasi M, Ferraiuolo L, Likhite S, Kaspar BK and Svendsen CN. (2014) Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after Suppression of mutant SOD1 in the motor cortex. J Neurosci. 34: 15587-600.

Shelley BC, Gowing G and Svendsen CN. (2014) A cGMP-applicable expansion method for aggregates of human neural stem and progenitor cells derived from pluripotent stem cells or fetal brain tissue. J Vis Exp. 15:(88).

Sareen D, Gowing G, Sahabian A, Staggenborg K, Paradis R, Avalos P, Latter J, Ornelas L, Garcia L and Svendsen CN. (2014) Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate in the rodent spinal cord. J Comp Neurol. 522: 2707-28.

The Huntington’s Disease iPSC Consortium* (2012) Induced pluripotent stem cells from patients with Huntington's Disease show CAG repeat-associated phenotypes. Cell Stem Cell 11: 264-278 (*Svendsen CN corresponding author).

Ebert AD, Barber AE, Heins BM and Svendsen CN. (2010) Ex vivo delivery of GDNF maintains motor function and prevents neuronal loss in a transgenic mouse model of Huntington's disease. Exp Neurol. 224: 155-162.

Ebert AD, Yu J, Rose F, Mattis VB, Lorson CL, Thomson JA and Svendsen CN. (2009) Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature. 457: 277-280. PMID: 19098894.

Behrstock S, Ebert A, McHugh J, Vosberg S, Moore J, Schneider B, Capowski E, Hei D, Kordower J, Aebischer P and Svendsen CN. (2006) Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates. Gene Ther. 13: 379-88.

Klein SM, Suzuki M, Behrstock S, McHugh J, Hoffmann K, Wallace W, Aebischer P and Svendsen CN. (2005) GDNF Delivery using human neural progenitor cells in a rat model of ALS. Human Gene Therapy 16: 509-21.

Gill SS, Patel NK, Hotton GR, O'Sullivan K, McCarter R, Bunnage M, Brooks DJ, Svendsen CN* and Heywood P. (2003) Direct brain infusion of glial cell line-derived neurotrophic factor (GDNF) in Parkinson's Disease. Nature Medicine 9: 589-595. PMID: 12669033. *Corresponding Author

Svendsen CN, Kew J, Staley K and Sofroniew MV. (1994) Death of developing septal cholinergic neurons following NGF withdrawal in vitro: protection by protein synthesis inhibition. J Neurosci. 14: 75-87.

Sofroneiw MV, Galletely NP, Isacson O and Svendsen CN. (1990) Survival of adult basal forebrain cholingergic neurons after loss of target neurons. Science 247: 338-342.

Thomsen G, Avalos P, Ma A, Alkaslasi M, Wyss L, Vit JP, Godoy M, Suezaki P, Shelest O, Bankiewicz, K, Svendsen CN. Transplantation of neural progenitor cells expressing GDNF into the motor cortex as a strategy to treat amyotrophic lateral sclerosis. Stem Cells

Das MM, Svendsen CN. Astrocytes show reduced support of motor neurons with aging that is accelerated in a rodent model of ALS. Neurobiol Aging. 2015;36(2):1130-1139.