Publications

See a complete PubMed list of publications by Stephan Targan, MD.


Selected Key Publications

Gonsky R, Fleshner P, Deem RL, Biener-Ramanujan E, Li D, Potdar AA, Bilsborough J, Yang S, McGovern DPB, Targan SR. Association of ribonuclease T2 gene polymorphisms with decreased expression and clinical characteristics of severity in Crohn’s disease. Gastroenterology. 2017 Jul;153(1):219-232. http://www.gastrojournal.org/article/S0016-5085(17)35412-4/fulltext.

Zhang H, Zheng L, McGovern DP, Hamill AM, Ichikawa R, Kanazawa Y, Luu J, Kumagai K, Cilluffo M, Fukata M, Targan SR, et al. Myeloid ATG16L1 facilitates host-bacteria interactions in maintaining intestinal homeostasis. J Immunol. 2017 Mar 1;198(5):2133-2146. http://www.jimmunol.org/content/198/5/2133.

Thomas LS, Targan SR, Tsuda M, Yu QT, Salumbides BC, Haritunians T, Mengesha E, McGovern DP, Michelsen KS. The TNF family member TL1A induces IL-22 secretion in committed human T(h)17 cells via IL-9 induction. J Leukoc Biol. 2017 Mar;101(3):727-737. http://www.jleukbio.org/content/101/3/727.

Tschurtschenthaler M, Adolph TE, Ashcroft JW, Niederreiter L, Bharti R, Saveljeva S, Bhattacharyya J, Flak MB, Shih DQ, Fuhler GM, Parkes M, Kohno K, Iwawaki T, Janneke van der Woude C, Harding HP, Smith AM, Peppelenbosch MP, Targan SR, et al. Defective ATG16L1-mediated removal of IRE1α drives Crohn’s disease-like ileitis. J Exp Med. 2017 Feb;214(2):401-422. http://jem.rupress.org/content/214/2/401.

Feagan BG, Sandborn WJ, Gasink C, Jacobstein D, Lang Y, Friedman JR, Blank MA, Johanns J, Gao LL, Miao Y, Adedokun OJ, Sands BE, Hanauer SB, Vermeire S, Targan S, et al. Ustekinumab as induction and maintenance therapy for Crohn’s disease. N Engl J Med. 2016 Nov 17;375(20):1946-1960. http://www.nejm.org/doi/full/10.1056/NEJMoa1602773.

Targan SR, Feagan B, Vermeire S, Panaccione R, Melmed GY, Landers C, Li D, Russell C, Newmark R, Zhang N, et al. A randomized, double-blind, placebo-controlled phase 2 study of brodalumab in patients with moderate-to-severe Crohn’s disease. Am J Gastroenterol. 2016 Nov;111(11):1599-1607. http://www.nature.com/ajg/journal/vaop/ncurrent/full/ajg2016298a.html?foxtrotcallback=true.

Li D, Achkar JP, Haritunians T, Jacobs JP, Hui KY, D'Amato M, Brand S, Radford-Smith G, Halfvarson J, Niess JH, Kugathasan S, Büning C, Schumm LP, Klei L, Ananthakrishnan A, Aumais G, Baidoo L, Dubinsky M, Fiocchi C, Glas J, Milgrom R, Proctor DD, Regueiro M, Simms LA, Stempak JM, Targan SR, et al. A pleiotropic missense variant in SLC39A8 is associated with Crohn’s disease and human gut microbiome composition. Gastroenterology. 2016 Oct;151(4):724-732. http://www.gastrojournal.org/article/S0016-5085(16)34759-X/fulltext.

Li D, Silverberg MS, Haritunians T, Dubinsky MC, Landers C, Stempak JM, Milgrom R, Guo X, Chen YD, Rotter JI, Taylor KD, McGovern DP, Targan SR. TNFRSF1B is associated with ANCA in IBD. Inflamm Bowel Dis. 2016 Jun;22(6):1346-1352. http://journals.lww.com/ibdjournal/pages/articleviewer.aspx?year=2016&issue=06000&article=00007&type=abstract.

Chu H, Khosravi A, Kusumawardhani IP, Kwon AH, Vasconcelos AC, Cunha LD, Mayer AE, Shen Y, Wu WL, Kambal A, Targan SR, et al. Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science. 2016 May 27;352(6289):1116-1120. http://science.sciencemag.org/content/352/6289/1116.

Sidhu-Varma M, Shih DQ, Targan SR. Differential levels of Tl1a affect the expansion and function of regulatory T cells in modulating murine colitis. Inflamm Bowel Dis. 2016 Mar;22(3):548-559. http://journals.lww.com/ibdjournal/pages/articleviewer.aspx?year=2016&issue=03000&article=00005&type=abstract.