The Wheeler Laboratory, led by Christopher J. Wheeler, PhD, investigates adaptive immunity and age-related immune dysfunction as it relates to disease, with particular focus on the central nervous system. Research areas include malignant brain tumor immunology and immunotherapy, the role of adaptive immune cells in neurodegenerative disorders such as Alzheimer’s disease, and immune dysfunction in neurodevelopmental conditions such as autism spectrum disorders. A major focus is on the use of brain tumor patient vaccine trial data to inform bench research for the purpose of improving clinical immunotherapy outcomes. In addition, we are studying the modulation of T cell recognition and homeostasis in central nervous system disease development and treatment.
Research projects in the Wheeler Laboratory all revolve around a central theme: the study of adaptive immunity and immune aging and their relationship to disorders of the central nervous system.
The Wheeler Laboratory is affiliated with the Maxine Dunitz Neurosurgical Institute, Samuel Oschin Comprehensive Cancer Institute, Neurosurgery Department and Graduate Program in Biomedical Science and Translational Medicine.