Molecular Models of Tumors

Our researchers are using a technique, known as electroporation, to understand the mechanisms of brain tumorgenesis and the necessary signaling pathways. Electroporation is a method for rapid genetic manipulation of neural stem cells in vivo. By understanding these mechanisms, we aim to create more targeted therapies.

In addition, because these models offer better approximations of human disease, we can more easily assess alternate modalities of treatments, such as immunotherapy.

• Principal Investigator: Joshua Breunig, PhD, and Moise Danielpour, MD

We are collaborating with:

• Department of Biomedical Sciences
• Department of Endocrinology
• Department of Neurosurgery
• Department of Pathology and Laboratory Medicine
• Regenerative Medicine Institute Brain Program
• Samuel Oschin Comprehensive Cancer Institute

• Breunig Laboratory