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Determinants of Liver Metastasis Program

The four projects examines different aspects of liver disease, but study overlapping signaling pathways common to the support or metastatic
Illustration shows the four projects that examines different aspects of liver disease, but study overlapping signaling pathways common to the support or metastatic

Projects


Graphic of Liver Metastasis Project 1

Project 1

Project Leader

Explores the acquisition of features that enable metastasis from circulating saturated fat and endoglin signaling in hepatocytes and cancer epithelia.

Graphic of Liver Metastasis Project 2

Project 2

Project Leader

Examines the pro-metastatic impact of hepatic stellate cell (HSC)-derived hyaluronic acids in non-alcoholic fatty liver disease.

Graphic of Liver Metastasis Project 3

Project 3

Project Leader

Studies the regulation and contribution of yes-associated protein (YAP) in creating a pro-metastatic liver microenvironment through the activation of a pro-cancer phenotypes of HSCs and macrophages.

Graphic of Liver Metastasis Project 4

Project 4

Project Leader

Investigates the roles of methionine adenosyltransferase (MAT) proteins in liver metastasis, from the loss of protective MAT1A to the pro-cancer elevated expression of MAT2A and MAT2B.

Cores


Medical Researcher hand pointing at data on computer monitor for Cedars-Sinai Biostatistics and Bioinformatics Core program.
Medical vials in a research facility for Cedars-Sinai Liver Metastasis Resource Core

Liver Metastasis Resource Core

Core Leader

Additional Resources