COVID-19

Our investigators have been at the forefront in discovery during the COVID-19 pandemic, have identified pathogenic mechanisms in COVID-19 and contributed to therapeutic development.

• Our work has led to a better understanding of why some patients develop severe disease after COVID-19.
  
  • Principal investigators: Peter Chen, MD, and Helen Goodridge, PhD

• We have developed novel models to study disease pathogenesis and for drug discovery.
  • Principal investigator: Barry Stripp, PhD

• Some COVID-19 patients have chronic symptoms (i.e., long COVID) that cause long-lasting disability. We have been trying to understand why some patients develop permanent lung dysfunction requiring oxygen supplementation and sometimes lung transplantation.
  • Principal investigators: Cory Hogaboam, PhD, Barry Stripp, PhD, Peter Chen, MD, and Tanyalak Parimon, MD
• We have worked closely with the CORALE study to understand mechanisms that prevent appropriate generation of neutralization antibodies after COVID-19 vaccination.
  • Principal investigators: Helen Goodridge, PhD, and Peter Chen, MD

Our investigators conducted clinical trials for COVID-19 treatments during the early days of the pandemic. Our work has led to the development of many of the current treatments used for COVID-19 patients.

• We were deeply involved with the ACTT study group trials that lead to the use of remdesivir and baricitinib for hospitalized COVID-19 patients.
  • Principal investigator: Victor F. Tapson, MD
• We participated in trials that led to the development of monoclonal antibodies as a therapy for mild-to-moderate COVID-19.
  • Principal investigator: Peter Chen, MD
• We are currently enrolling patients into the RECOVER trial, which has the goal to understand mechanisms that lead to long COVID.
  • Principal Investigator: Peter Chen, MD
• We are part of the STRIVE clinical trials network and continue to evaluate novel interventions for the treatment of hospitalized patients with COVID-19.
  • Principal Investigator: Peter Chen, MD

• Susan Cheng, MD
• Caroline Jefferies, PhD
• Jonathan G. Braun, MD, PhD
• Stanley C. Jordan, MD

• Chen Laboratory
• Goodridge Laboratory
• Hogaboam Laboratory
• Parimon Laboratory
• Stripp Laboratory