With annual treatment costs estimated in the billions, lung disease is the third-leading cause of death in the United States. The mission in the Lung Program at the Cedars-Sinai Regenerative Medicine Institute is to use lung stem cells to identify critical determinants of lung epithelial maintenance, renewal and remodeling that can lead to more effective therapies for lung diseases.
The Lung Program focuses on fibroproliferative lung diseases—idiopathic pulmonary fibrosis (IPF) and bronchiolitis obliterans syndrome (BOS). For these lung diseases, the mechanism of disease inhalation and progression are poorly understood, and prognosis is poor due to the lack of effective treatment options. End-stage IPF and BOS are characterized by dysfunctional epithelium, coupled with expansion of underlying mesenchyme and deposition of extra cellular matrix leading to respiratory failure.
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Board of Governors Regenerative Medicine Institute
Pavilion, Eighth Floor
8700 Beverly Blvd.
Los Angeles, CA 90048