Publications

Koronyo Y, Rentsendorj A, Mirzaei N, Regis GC, Sheyn J, Shi H, Barron E, Cook-Wiens G, Rodriguez AR, Koronyo-Hamaoui M, et al. Retinal pathological features and proteome signatures of Alzheimer's disease. Acta Neuropathol. 2023 Apr;145(4):409-438. doi: 10.1007/s00401-023-02548-2. Epub 2023 Feb 11. PMID: 36773106; PMCID: PMC10020290.

Shi H, Yin Z, Koronyo Y, Fuchs DT, Sheyn J, Davis MR, Wilson JW, Margeta MA, Pitts KM, Koronyo-Hamaoui M, et al. Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer's-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia. Acta Neuropathol Commun. 2022 Sep 8;10(1):136. doi: 10.1186/s40478-022-01439-z. PMID: 36076283; PMCID: PMC9461176.

Du X, Koronyo Y, Mirzaei N, Yang C, Fuchs DT, Black KL, Koronyo-Hamaoui M, Gao L. Label-free hyperspectral imaging and deep-learning prediction of retinal amyloid β-protein and phosphorylated tau. PNAS Nexus. 2022 Aug 19;1(4):pgac164. doi: 10.1093/pnasnexus/pgac164. PMID: 36157597; PMCID: PMC9491695.

Vit JP, Fuchs DT, Angel A, Levy A, Lamensdorf I, Black KL, Koronyo Y, Koronyo-Hamaoui M. Color and contrast vision in mouse models of aging and Alzheimer's disease using a novel visual-stimuli four-arm maze. Sci Rep. 2021 Jan 13;11(1):1255. doi: 10.1038/s41598-021-80988-0. PMID: 33441984.

Doustar J, Regis GC, Torbati T, Fuchs DT, Sheyn J, Rentsendorj A, Graham SL, Shah PK, Mastali M, Van Eyk JE, Black KL, Gupta VK, Mirzaei M, Koronyo Y, Koronyo-Hamaoui M. Parallels between retinal and brain pathology and response to immunotherapy in old, late-stage mouse AD models. Aging Cell. 00:e13246 (2020). doi: 10.1111/acel.13246.

Shi H, Koronyo Y, Rentsendorj A, Regis GC, Sheyn J, Fuchs DT, Kramerov AA, Ljubimov AV, Dumitrascu OM, Koronyo-Hamaoui M, et al. Identification of early pericyte loss and vascular amyloidosis in Alzheimer's disease retina. Acta Neuropathol. 2020 May;139(5):813-836. doi: 10.1007/s00401-020-02134-w. Epub 2020 Feb 10. PMID: 32043162; PMCID: PMC7181564.

Koronyo-Hamaoui M, Sheyn J, Hayden EY, Li S, Fuchs DT, Regis GC, Lopes DHJ, Black KL, Bernstein KE, Teplow DB, Fuchs S, Koronyo Y, Rentsendorj A. Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease. Brain. 143(1): 336-358 (2020). PMID: 31794021

Li S, Hayden EY, Garcia VJ, Fuchs DT, Sheyn J, Daley DA, Rentsendorj A, Torbati T, Black KL, Rutishauser U, Teplow DB, Koronyo Y, Koronyo-Hamaoui M. Activated Bone Marrow-derived Macrophages Eradicate Alzheimer’s-Related Aβ42 Oligomers and Protect Synapses. Frontiers in Immunology. 11:49 (2020). PMID: 32082319.

Rentsendorj A, Sheyn J, Fuchs DT, Daley D, Salumbides BC, Schubloom HE, Hart NJ, Li S, Hayden EY, Teplow DB, Black KL, Koronyo Y, Koronyo-Hamaoui M. A novel role for osteopontin in macrophage-mediated amyloid-β clearance in Alzheimer’s models. Brain Behav Immun. 67:163-180 (2018). PMID: 28860067

Koronyo Y, Biggs D, Barron E, Boyer DS, Pearlman JA, Au WJ, Kile SJ, Blanco A, Fuchs DT, Koronyo-Hamaoui M, et al. Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer’s disease. JCI Insight. 2(16):e93621 (2017). PMID: 28814675.

Bernstein KE, Koronyo Y, Salumbides B, Sheyn J, Pelissier L, Lopes DHJ, Kandarp SH, Bernstein EA, Fuchs DT, Koronyo-Hamaoui M, et al. Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer's-like cognitive decline. J Clin Invest. 124(3): 1000-1012 (2014). PMID: 24487585.

Study: Alzheimer's Signs Appear in Eye (KTLA 5, Apr. 2023)

Your eyes may be a window into early Alzheimer's detection (Connie Chang, National Geographic. Apr. 2023)

Eye Changes May Reveal Early Signs of Alzheimer’s Disease (Becky Upham, Everyday Health, Mar. 2023)

Eye exams could help detect Alzheimer’s disease (Stephanie Whiteside, News Nation, Mar. 2023)

Unraveling the Mystery of Eye Damage in Alzheimer’s Disease Patients (SciTechDaily, Mar. 2023)

Alzheimer’s disease changes may be reflected in the eyes first (Lynda Charters, Ophthalmology Times, Mar. 2023)

Early Alzheimer’s disease could be diagnosed through eye exams, new study suggests (Melissa Rudy, Fox News, Mar. 2023)

Alzheimer’s first signs may appear in your eyes, study finds (Sandee LaMotte, CNN, Mar. 2023)

New insights: Eye damage in Alzheimer’s disease patients (National Eye Institute, Mar. 2023)

Take care of your senses: The science behind sensory loss and dementia risk (Chip Rose, National Institute on Aging Research Highlights, Jan. 2023)

Israeli-U.S. research uses retina to detect Alzheimer's disease (Judy Siegel-Itzkovich, Jerusalem Post, Sep. 2022)

Our eyes may provide early warning signs of Alzheimer’s and Parkinson’s (Elizabeth Anne Brown, The Washington Post, Feb. 2021)

The Eyes Offer A ‘Promising Window’ Into Brain Pathology (Deborah Borfitz, Diagnostics World, Dec. 2020)

Scientists Are Looking Into The Eyes Of Patients To Diagnose Parkinson’s Disease (Jackie Rocheleau, Forbes, Nov. 2020)

Amyloid in the Retina Correlates With Alzheimer's Brain Changes (Pauline Anderson, Medscape, Nov. 2020)

Blood Vessel Defects in Eyes May Foretell Alzheimer's (NewsWise, June 2020)

AlzForum Notation on Acta Neuropathol 2020 (AlzForum, May 2020)

Retina study eyes Alzheimer’s processes to target for early screening (NIH/NIA Featured Research, April 2020)

Quasi-Lymphatic System in the Rodent Eye Clears Waste (Abby Olena, The Scientist, Apr. 2020)

Enhanced Immune Cells Resist Alzheimer's, Preserve Cognition in Mice (Sarah Lichtman, Cedars-Sinai Newsroom, Feb. 2020)

Viewing Retinal Vasculature in Alzheimer’s Disease (Christine A. Curcio, PhD, Jama Opthalmology, Aug. 2018)

Does Retinal Thinning Reflect Early Alzheimer’s? (Tom Fagan, Alzforum, Aug. 2018)

Controversies and Future Directions of Ocular Biomarkers in Alzheimer Disease (Sally S. Ong, MD, P. Murali Doraiswamy, MBBS, FRCP, Eleonora M. Lad, MD, PhD, Viewpoint. JAMA Neurology 75(6), June 2018)

A Retinal Scan for Alzheimer's Disease (Jennifer Abbasi, JAMA, Oct. 2017;318(14):1314)

Retinal Plaques May Enable Noninvasive Screening for AD (Madolyn Bowman Rogers, Alzforum, Sep. 2017)

Retinal Amyloid Imaging Shines a Light on Alzheimer's Disease (Richard Robinson, Neurology Today, Dec. 2017)

Noninvasive imaging of retinal amyloid deposits in patients with Alzheimer's disease (Editor's Pick, JCI This Month, Sep. 2017)

Member in the news: Maya Koronyo-Hamaoui investigates eye scan as early detection of Alzheimer's disease (Alzheimer's Association Membership News, Sept. 2017)

Eye scan could spot Alzheimer's decades before symptoms emerge (Mark Waghorn, New York Post, Aug. 2017)

Can this eye scan detect Alzheimer's years in advance? (Sean Rossman, USA TODAY, Aug. 2017)

New eye test could spot Alzheimer's disease 20 YEARS before symptoms emerge (Mia de Graaf, DailyMail.com, Aug. 2017)

An Eye Scan for Alzheimer's Disease? (Shawna Williams, The Scientist, Nov. 2017)

High-definition eye scan could reveal crucial warning signs of Alzheimer's disease (News-Medical.net, Aug. 2017)

Eye scans could detect Alzheimer's years before symptoms develop (Ed Mason, Science Recorder, Aug. 2017)

Alzheimer's may mess with the eyes, disrupting sleep patterns (Lindzi Wessel, Science, Dec. 2015)

Therapeutic effects of glatiramer acetate and grafted CD115+ monocytes in a mouse model of Alzheimer's disease (Editor's Choice, Brain, Aug. 2015)

Koronyo-Hamaoui study named August 'Editor's Choice' in Brain (Barbara Ivey, CART News, Jul. 2015)

Blood Pressure Protein Could Rid Alzheimer's Brain Of Amyloid Plaques (Anthony Rivas, Medical Daily, Feb. 2014)

A Protein Controlling Blood Pressure Can Enhance Immune Cells to Attack Alzheimer's Plaques (Martha Snyder Taggart, BrightFocus Foundation Science News, Feb. 2014)

The Hidden Benefit of ACE: Alzheimer's Disease Prevention (Shawn Radcliffe, Healthline, Feb. 2014)

Can We Predict Alzheimer's a Decade Before Symptoms? (Dr. Sanjay Gupta, CNN Health, Aug. 2013)

The Retina Provides a Window to the Brain for Early Alzheimer's Diagnosis (Dr. Maya Koronyo-Hamaoui, Advances in Neurology and Neurosurgery, Sep. 2010)

Identification of Retinal Amyloid Pathology and In vivo Retinal Plaque Imaging (Trimed Staff, HealthImaging, Jul. 2010)

Alzheimer's Diagnosis by Retina? (Gearoid Tuohy, EuroTimes, 2010;15(11))

Additional news coverage by NPR, Fox News, NBC, KCRW and more…

Pioneer in Medicine Award '2013' to Maya and Yosef Koronyo from Society for Brain Mapping and Therapeutics

BrightFocus® Foundation Awards, Maya Koronyo-Hamaoui, PhD

Coins for Alzheimer's Research Trust Awards their First Grant to a Woman Researcher, Maya Koronyo-Hamaoui, PhD