Publications
See a complete PubMed list of publications by Mehrnoosh Saghizadeh Ghiam, PhD.
Selected Key Publications
- Leszczynska A, Kulkarni M, Ljubimov AV, Saghizadeh M. Exosomes from normal and diabetic human corneolimbal keratocytes differentially regulate migration, proliferation and marker expression of limbal epithelial cells. Sci Rep. 2018 Oct 11;8(1):15173. https://www.nature.com/articles/s41598-018-33169-5.
- Saghizadeh M, Kramerov AA, Svendsen CN, Ljubimov AV. Stem cell for corneal wound healing. Stem Cells. 2017 Oct;35(10):2105-2114. https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/stem.2667.
- Kulkarni M, Leszczynska A, Wei G, Winkler MA, Tang J, Funari VA, Deng N, Liu Z, Punj V, Deng SX, Ljubimov AV, Saghizadeh M. Genome-wide analysis suggests a differential microRNA signature associated with normal and diabetic human cornal limbus. Sci Rep. 2017 Jun 14;7(1):3448. http://www.nature.com/articles/s41598-017-03449-7.
- Jones M, Lu B, Saghizadeh M, Wang S. Gene expression changes in the retina following subretinal injection of human neural progenitor cells into a rodent model for retinal degeneration. Mol Vis. 2016 May 16;22:472-490. http://www.molvis.org/molvis/v22/472/.
- Kramerov AA, Saghizadeh M, Ljubimov AV. Adenoviral gene therapy for diabetic keratopathy: effects on wound healing and stem cell marker expression in human organ-cultured corneas and limbal epithelial cells. J Vis Exp. 2016 Apr 7;110:e54058. https://www.jove.com/video/54058/adenoviral-gene-therapy-for-diabetic-keratopathy-effects-on-wound.
- Kramerov AA, Saghizadeh M, Maguen E, Rabinowitz YS, Ljubimov AV. Persistence of reduced expression of putative stem cell markers and slow wound healing in cultured diabetic limbal epithelial cells. Mol Vis. 2015 Dec 30;21:1357-1367. http://www.molvis.org/molvis/v21/1357/.
- Ljubimov AV, Saghizadeh M. Progress in corneal wound healing. Prog Retin Eye Res. 2015 Nov;49:17-45. http://www.sciencedirect.com/science/article/pii/S135094621500049X.
- Winkler MA, Dib C, Ljubimov A, Saghizadeh M. Targeting miR-146a to treat delayed wound healing in diabetic organ-cultured corneas. PLOS One. 2014;9(12):e114692. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114692.
- Saghizadeh M, Dib CM, Brunken WJ, Ljubimov AV. Normalization of wound healing and stem cell marker patterns in organ-cultured human diabetic corneas by gene therapy of limbal cells. Exp Eye Res. 2014 Dec;129:66-73. http://www.sciencedirect.com/science/article/pii/S0014483514002954.
- Sareen D, Saghizadeh M, Ornelas L, Rostamiani K, Winkler MA, Narwani K, Sahabian A, Spurka L, Tang J, Funari VA, et al. Differentiation of human limbal-derived induced pluripotent stem cells into limbal-like epithelium. Stem Cells Transl Med. 2014;3(9):1002-1012. https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.5966/sctm.2014-0076.
- Saghizadeh M, Epifantseva I, Hemmati D, Ghiam C, Dib C, Brunken WJ, Ljubimov AV. Enhanced wound healing, kinase and stem cell marker expression in diabetic organ-cultured human corneas upon MMP-10 and cathepsin F gene silencing. Invest Ophthalmol Vis Sci. 2013;54(13):8172-8180. http://iovs.arvojournals.org/article.aspx?articleid=2127948.
- Funari VA, Winkler MA, Brown J, Dimitrijevich SD, Ljubimov AV, Saghizadeh M. Differentially expressed wound healing-related microRNAs in the human diabetic cornea. PLOS One. 2013;8(12):e84425. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084425.
- Saghizadeh M, Winkler MA, Kramerov AA, Sareen D, Ornelas L, David Hemmati D, Ghiam CA, Ghiasi H, Dimitrijevich SD, Brunken WJ, et al. A simple alkaline method for decellularizing human amniotic membrane for cell culture. PLOS One. 2013;8(11):e79632. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079632.
- Saghizadeh M, Soleymani S, Harounian A, Bhakta B, Troyanovsky SM, Brunken WJ, Pellegrini G, Ljubimov AV. Alterations of epithelial stem cell marker patterns in human diabetic corneas and effects of c-met gene therapy. Mol Vis. 2011;17:2177-2190. http://www.ncbi.nlm.nih.gov/pubmed/21866211.
- Saghizadeh M, Kramerov AA, Yu FS, Castro MG, Ljubimov AV. Normalization of wound healing and diabetic markers in organ cultured human diabetic corneas by adenoviral delivery of c-met gene. Invest Ophthalmol Vis Sci. 2010;51(4):1970-1980. http://iovs.arvojournals.org/article.aspx?articleid=2185877.
Contact the Saghizadeh Ghiam Lab
Advanced Health Sciences Pavilion, Suite A8104
127 S. San Vicente Blvd.
Los Angeles, CA 90048