Research Areas

Our research examines Type 2 diabetes, insulin resistance and the biology of aging, including mitochondrial dysfunction, cellular senescence and exercise adaptations, to identify therapies that improve metabolic health and healthspan.

We investigate the mechanisms underlying Type 2 diabetes, including insulin resistance, impaired glucose regulation and dysfunction in skeletal muscle and other metabolic tissues. Our clinical and mechanistic research aims to identify therapeutic targets and evaluate approaches to prevent and treat metabolic disease.

We examine insulin signaling, glucose uptake and metabolic flexibility in human skeletal muscle, including how these processes are altered by diabetes, obesity and aging.

We study mitochondrial function, energy metabolism and cellular stress responses to understand their contributions to insulin resistance, diabetes and age-related decline.

We investigate fundamental mechanisms of biological aging and how they contribute to chronic disease and loss of physical function. Our geroscience research seeks to identify interventions that target aging-related processes to improve metabolic health, resilience and healthspan.

We use exercise training and physiological studies to understand how physical activity affects insulin sensitivity, mitochondrial function and age-related changes in muscle and systemic metabolism.

Our human studies integrate clinical outcomes, physiological testing and molecular analyses to evaluate treatments for Type 2 diabetes and interventions intended to preserve function during aging. Specific ongoing studies and enrollment details should be confirmed before publication.