The mission of the Svendsen Laboratory is to study neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), spinal muscular atrophy (SMA), Parkinson’s disease (PD) and Allan-Herndon-Dudley syndrome (AHDS) using stem cells as a disease treatment, as well as a tool for modeling these diseases in vitro. Clive Svendsen, PhD, has significant experience in studying these diseases over the last twenty years and is merging his experience with the use of leading-edge technologies, such as inducible pluripotent stem cells (iPS cells).
Svendsen also pursues many collaborative efforts with other researchers interested in the use of neural progenitor cells for the treatment of stroke and macular degeneration.
The Svendsen Laboratory is affiliated with the Regenerative Medicine Institute and Department of Biomedical Sciences.
Amyotrophic lateral sclerosis (ALS or Lou Gehrig’s disease) is a devastating and lethal disease resulting in the degeneration of neurons located in the brain and spinal cord responsible for controlling muscle function. Progression from early muscle twitches to complete paralysis and death usually happens within four years. There is currently no cure for ALS and only one approved therapeutic agent, Riluzole, which has been shown to minimally slow the progress of the disease.
- Answer ALS
- CIRM ALS - $18 Million ALS Research Grant for Stem Cell Therapy Applauded by ALS Advocates video
- CIRM ALS - Progress Toward Stem Cell Therapies for ALS video
- Allison D. Ebert, PhD
- Huntington's Disease Stem Cell Research - Log in required
Meet Our Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Svendsen Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Vatine G, Al-Ahmad A, Barriga B, Svendsen S, Salim A, Garcia L, Garcia V, Ho R, Yucer N, Qian T, Lim R, Wu J, Thompson L, Spivia W, Chen Z, Van Eyke J, Palecek S, Refetoff S, Shuster E and Svendsen CN.
Cell Stem Cell 20(6): 831-843.
Rushton D, Andres P, Allred P, Baloh R and Svendsen CN.
Ho R, Sances S, Gowing G, Amoroso MW, O’Roarke JG, Shabian A, Wichterle H, Baloh RH, Sareen D and Svendsen CN.
Nature Neuroscience 19(9):1256-67.
Contact the Svendsen Lab
127 S. San Vicente Blvd.
Pavilion, Room 8405
Los Angeles, CA 90048