J. Yang Lab
The Yang Lab is dedicated to advancing clinical and translational research to improve the diagnosis, prognostication and treatment response assessment of hepatocellular carcinoma (HCC). Our work integrates population-based cohort studies, cutting-edge molecular profiling and innovative liquid biopsy techniques to develop groundbreaking solutions for liver cancer care. Central to our mission is the identification and validation of novel circulating biomarkers, including extracellular vesicle-based digital scores and circulating tumor cell assays. These discoveries aim to revolutionize early cancer detection and enable personalized treatment strategies. Supported by multiple NIH/NCI-funded projects, our lab employs advanced nanotechnologies and big data analytics to uncover critical molecular signatures, refine surveillance models and improve patient outcomes. Through collaboration, innovation and rigorous scientific inquiry, the Yang Lab is shaping the future of liver cancer research.
Personal Statement
As a physician-scientist, I am committed to advancing the clinical management of hepatocellular carcinoma (HCC) through interdisciplinary research and innovation. My work bridges clinical epidemiology, modeling studies and molecular biomarker discovery to enhance early detection, prognostication and treatment response assessment in liver cancer. With support from NIH-funded projects and strong collaborative partnerships, my lab strives to translate leading-edge research into patient-centered strategies that improve diagnosis, optimize treatment pathways and extend survival. By integrating scientific rigor with a focus on real-world impact, I aim to contribute to a future where HCC outcomes are significantly transformed.
Ju Dong Yang, MD
Breakthrough Research
The Yang Lab is dedicated to advancing the early detection and risk stratification of hepatocellular carcinoma (HCC) through the discovery and validation of circulating biomarkers, including circulating tumor cells and extracellular vesicles. By integrating these insights with predictive modeling and molecular profiling, the lab develops precision therapies tailored to individual patients and optimizes treatment responses. Leveraging population-based data, the Yang Lab also addresses global disparities in liver cancer care, guiding more equitable and effective clinical strategies. Our work emphasizes noninvasive, patient-centered approaches that refine surveillance methods, enhance diagnostic accuracy, and ultimately, improve outcomes for individuals affected by liver cancer.
Publications
Learn more about the recent research publications from the J. Yang Lab.
Laboratory Team
Learn more about the J. Yang Laboratory team, whose dedicated efforts lead to groundbreaking discoveries.
Collaborations
The J. Yang Lab collaborates with a wide range of investigators within Cedars-Sinai and in institutions around the world.
- Euichang Kim—Senior Clinical Fellow, Asan Medical Center
- Sangbin Han, MD, PhD—Associate Professor, Samsung Seoul Hospital
- Dong Hyun Shin, MD, PhD—Professor, Samsung Medical Center
- Gwang Hyeon Choi, MD, PhD—Associate Professor, Seoul National University Bundang Hospital
- Ji Hye Min, MD, PhD—Assistant Professor, Samsung Medical Center Sungkyunkwan University School of Medicine
- Huisong Lee, MD, PhD—Assistant Professor, Ewha Woman's University Mokdong Hospital
- Young Eun Chon, MD, PhD—Associate Professor, CHA Bundang Medical Center, CHA University College of Medicine
- Jinsoo Rhu, MD—Professor of Surgery, Samsung Medical Center
- Minsun Kwak, MD, PhD—Professor, Seoul National University Hospital Healthcare System Gangnam Center
- Jeong Ah Hwang, MD—Assistant Professor, Samsung Medical Center
- Ye Rim Kim, MD—General Physician, Asan Medical Center
- Wei Yuan, MD—Associate Chief Physician, The First Hospital of Hunan University of Chinese Medicine
- NaHee Lee, MD, PhD—Associate Professor, Cha Bundang Medical Center
- Sang Yun Han, MD—Professor, Samsung Medical Center
- Danbi Lee, MD—Professor, Asan Medical Center
Contact the J. Yang Lab
Comprehensive Transplant Center
8900 Beverly Blvd., 252A
Los Angeles, CA 90048