Mavila Lab
The Mavila Laboratory is interested in understanding the molecular mechanisms that regulate liver regeneration during acute and chronic liver injuries, and how sustained and chronic injuries contribute to the development of liver fibrosis and cancer. Ongoing studies focus on understanding the intrinsic signaling pathways and cellular cross talk among hepatocytes, hepatic stellate cells (HSC), cholangiocytes and immune cells during chronic liver injury, and their role in the development of liver fibrosis. To achieve this, we utilize various in vivo and in vitro experimental models, including organoids, multicellular spheroids and spatial omics methodologies.
Personal Statement
Our research focuses on understanding the mechanisms that promote progressive liver fibrosis and cancer. Our long-term goal is to identify novel therapeutic targets and develop targeted therapies to treat chronic diseases such as liver fibrosis and cancer.
Nirmala Mavila, PhD
Breakthrough Research
- Molecular mechanism of bridging liver fibrosis
- Pathophysiological role of ductular reaction and portal inflammation associated with chronic liver injury
- Mechanism of dysregulated liver regeneration during chronic liver injury
- Liver cancer stem cells
Publications
Learn more about the recent research publications from the Mavila Lab.
Laboratory Team
Learn more about the Mavila Laboratory team, whose dedicated efforts lead to groundbreaking discoveries.
Job Opportunities
We are actively recruiting talented individuals to join our laboratory, bringing their expertise to make important breakthroughs.
Collaborations
The Mavila Lab collaborates with a wide range of investigators within Cedars-Sinai.
Contact the Mavila Lab
8700 Beverly Blvd.
Davis Building, Suite 3094C
Los Angeles, CA 90048