Publications

Ho R, Workman MJ, Mathkar P, Wu K, Kim KJ, O’Rourke JG, Kellogg M, Montel V, Banuelos MG, Aladesuyi O, Diaz-Garcia S, Oheb D, Huang S, Khrebtukova I, Watson L, Ravits J, Taylor K, Baloh RH, Svendsen CN. Cross-Comparison of Human iPSC Motor Neuron Models of Familial and Sporadic ALS Reveals Early and Convergent Transcriptomic Disease Signatures. Cell Systems. 2021 Feb 17;12.

Ho R, Sances S, Gowing G, Amoroso MW, O’Rourke JG, Sahabian A, Wichterle H, Baloh RH, Sareen D, Svendsen CN. ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks. Nat Neurosci. 2016 Sep;19(9):1256-1267.

Laperle AH, Sances S, Yucer N, Dardov VJ, Garcia VJ, Ho R, Fulton A, Jones MR, Roxas K, Avalos P, et al. iPSC modeling of young onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates. Nat Med. 2020 Feb;26(2):289-299. 

Sances S, Ho R, Vatine G, West D, Laperle A, Meyer A, Godoy M, Kay PS, Mandefro B, Hatata S, et al. Human iPSC-derived endothelial cells and microengineered Organ-Chip enhance neuronal development. Stem Cell Reports. 2018 Apr 10;10(4):1222-1236.

O’Rourke JG, Bogdanik L, Yáñez A, Lall D, Wolf AJ, Muhammad AK, Ho R, Carmona S, Vit JP, Zarrow J, et al. C9orf72 is required for proper macrophage and microglial function in mice. Science. 2016 Mar 18;351(6279):1324-1329. 

O’Rourke, JG, Bogdanik L, Muhammad AKMG, Gendron TF, Kim KJ, Austin A, Cady J, Liu EY, Zarrow J, Grant S, Ho R, et al. C9orf72 BAC transgenic mice display typical pathologic features of ALS/FTD. Neuron. 2015 Dec 2;88(5):892-901. 

Ho R*, Papp B*, Hoffman JA, Merrill BJ, Plath K. Stage-specific regulation of reprogramming to induced pluripotent stem cells by Wnt signaling and T cell factor proteins. Cell Rep. 2013 Jun 27;3(6):2113-2126. (*equal contribution)