Guided by the hypothesis that biomarkers associated with disease progression can provide a window into the biology of the cancer, the lab is specifically interested in:
- Cell-cell interactions that involve signaling molecules secreted from one cell that elicit a response in the neighboring cell – paracrine and juxtacrine signaling;
- The subsequent cytoplasmic signals that dictate cell proliferation, differentiation, and adaptation to the microenvironment of the bone metastatic site;
- Identify ingdiagnostic/prognostic biomarkers of prostate cancer that non-invasively distinguish indolent vs. metastatic disease;
- Determining the role of stromal heterogeneity in cancer initiation and progression to therapeutic resistance;
- Understanding the role of bone cells in prostate metastatic growth;
- Determining mechanisms of targeted therapy for renal and prostate cancer.