The goal of the Knott Laboratory is to develop cancer treatment strategies that are focused on the hetero-cellular interactions within tumors that drive disease progression. This work entails developing and interrogating models of resistance to already established as well as experimental therapies. In addition, the Knott Lab applies novel profiling methods to study patient tumors so that the cellular interactions driving the diseased tissue can be ascertained. By applying the knowledge gained from studying clinical material to focus questions asked of the model systems, the Knott Lab hopes to identify rationally guided therapeutic strategies to halt disease progression.
The Knott Laboratory is affiliated with the Cedars-Sinai Department of Biomedical Sciences.