See a complete PubMed list of publications by Kathrin Michelsen, PhD.

Selected Key Publications

Thomas LS, Targan SR, Tsuda M, Yu QT, Salumbides BC, Haritunians T, Mengesha E, McGovern DP, Michelsen KS. The TNF family member TL1A induces IL-22 secretion in committed human Th17 cells via IL-9 induction. J Leukoc Biol. 2017 Mar;101(3):727-737.

Zonis S, Pechnick RN, Ljubimov VA, Mahgerefteh M, Wawrowsky K, Michelsen KS, Chesnokova V. Chronic intestinal inflammation alters hippocampal neurogenesis. J Neuroinflammation. 2015 Apr 3;12:65.

Michelsen KS, Wong MH, Ko B, Thomas LS, Dhall D, Targan SR. HMPL-004 (Andrographis paniculata extract) prevents development of murine colitis by inhibiting T cell proliferation and TH1/TH17 responses. Inflamm Bowel Dis. 2013; Jan;19(1):151-164.

Lowe EL, Crother TR, Rabizadeh S, Hu B, Wang H, Chen S, Shimada K, Wong MH, Michelsen KS, Arditi M. TLR2 signaling protects mice from tumor development and growth in a mouse model of colitis-associated cancer. PLOS ONE. 2010 Sep 27;5(9):e13027.

Michelsen KS, Thomas LS, Taylor KD, Yu QT, Mei L, Landers CJ, Derkowski C, McGovern DPB, Rotter JI, Targan SR. IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein. PLOS ONE. 2009;4(3):e4719.

Takedatsu H, Michelsen KS, Bo W, Landers CJ, Thomas LS, Dhall D, Braun J, Targan SR. TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper (TH) 1 and TH17 activation. Gastroenterology. 2008 Aug;135(2):552-567.

Prehn JL, Thomas LS, Landers CJ, Yu QT, Michelsen KS, Targan SR. The T cell costimulator TL1A is induced by FcγR signaling in human monocytes and dendritic cells. J Immunol. 2007 Apr 1;178(7):4033-4038.

Michelsen KS, Arditi M. Toll-like receptors and innate immunity in gut homeostasis and pathology. Curr Opin Hematol. 2007 Jan;14(1):48-54.

Rosenkranz ME, Schulte DJ, Agle LMA, Wong MH, Zhang W, Efthimiou P, Ivashkiv L, Doherty TM, Fishbein MC, Lehman TJA, Michelsen KS, Arditi M. TLR2 and MyD88 contribute to Lactobacillus casei extract–induced focal coronary arteritis in a mouse model of Kawasaki disease. Circulation. 2005;112(19):2966.

Fukata M, Eri R, Michelsen KS, Thomas LS, Hu B, Lukasek K, Nast CC, Lechago J, Xu R, Naiki Y, et al. Toll-like receptor 4 (TLR4) is required for the intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis. Am J Physiol Gastrointest Liver Physiol. 2005 May;288(5):G1055-1065.

Michelsen KS, Doherty TM, Shah PK, Arditi M. TLR signaling: an emerging bridge from innate immunity to atherogenesis. J Immunol. 2004 Nov 15;173(10):5901-5907.

Michelsen KS, Wong MH, Shah PK, Zhang W, Yano J, Doherty TM, Akira S, Rajavashisth TB, Arditi M. Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci USA. 2004;Jul 20;101(29):10679-10684.