Murali Laboratory

Structural Biology and Molecular Therapeutics

Research in the Murali Laboratory focuses on defining the molecular basis of drug resistance mechanisms and cancer metastasis, and on developing new targeted therapeutic drugs. To learn the interplay between immunity and cancer, studies are focused on the role of the tumor necrosis factor receptors and the epidermal growth factor receptors in breast, lung and pancreatic cancers. The Murali Lab employs protein engineering, X-ray diffraction, molecular biology and computational biology for drug discovery and for developing molecular probes for tumor imaging and drug delivery.

The Murali Laboratory is affiliated with the Cedars-Sinai Biomedical Imaging Research Institute and the Cedars-Sinai Research Division of Immunology in the Department of Biomedical Sciences.