I have been engaged in the study of inflammatory bowel disease (IBD) for nearly four decades and have been treating patients with IBD during this time. My research interests span clinical, basic and translational research and are primarily focused on immunopathologic mechanisms, novel therapeutics and the translation of basic science and genetic findings for use in diagnosis, prognosis and targeted therapeutic selection in IBD.
My lab team is now using stem cell technology to develop genetically select models of human IBD that greatly facilitate our ability to understand the complex interactions that make up these diseases and, potentially, may be developed in future therapeutic approaches. Human in vitro and animal models are also used in genetic and immunobiologic investigations to elucidate the dysregulated immune responses in the gastrointestinal tract that lead to mucosal inflammation.
My goal is to combine all of these areas so that the right patients get the right treatment, at the right time and in the right way. I have enjoyed the opportunity to train more than 100 students, fellows and postdoctoral researchers over the course of my career.