Areas of research in the Crother Laboratory include acute lung infections and host-pathogen interactions, in addition to allergic asthma models. The Crother Lab also investigates the mechanisms by which RIP2 in T cells controls the induction of pathogenic Th17 skewing and its implication in inflammatory bowel disease mouse models. Finally, we are studying how C. pneumoniae infections can modulate Alzheimer’s disease progression.
The Crother Laboratory is affiliated with the Infectious and Immunologic Diseases Research Center, Department of Biomedical Sciences and the Pediatrics Department.
As a researcher, one of my key interests has centered on host-pathogen interactions. This has led me to investigate how Borrelia burgdorferi, the causative agent of Lyme Disease, remakes itself when it infects a mammalian host, and how Chlamydia pneumoniae infections can drive asthmatic responses, and also exacerbate atherosclerotic plaque development. More recently, I have become interested in the possibility that infectious agents may play a role in the development and progression of Alzheimer’s Disease. While there is evidence that infections may play a role in AD, few direct studies have been attempted, highlighting the need for new investigations.
Timothy R. Crother, PhD
- The Role of Infectious Diseases in the Etiology of Alzheimer’s Disease
- T-cell RIP2 and Inflammatory Bowel Disease
- Pulmonary Infections
- Innate Immunity and Asthma
Meet Our Team
Learn more about the researchers of the Crother Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Dagvadorj J, Mikulska-Ruminska K, Tumurkhuu G, Ratsimandresy RA, Carriere J, Andres AM, Marek-Iannucci S, Song Y, Chen S, Lane M, Dorfleutner A, Gottlieb RA, Stehlik C, Cassel S, Sutterwala FS, Bahar I, Crother TR, Arditi M.
Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2015632118.
Shimada K, Porritt RA, Markman JL, O’Rourke JG, Wakita D, Rivas MN, Ogawa C, Kozhaya L, Martins GA, Unutmaz D, Baloh RH, Crother TR, Chen S, Arditi M.
Immunity. 2018 Nov 20;49(5):873-885.e7.
Crother TR, Porritt RA, Dagvadorj J, Tumurkhuu G, Slepenkin AV, Peterson EM, Chen S, Shimada K, Arditi M.
Front Immunol. 2019 Apr 12;10:75.
Chiba N, Shimada K, Chen S, Jones HD, Alsabeh R, Slepenkin AV, Peterson E, Crother TR, Arditi M.
J Immunol. 2015 Apr 15;194(8):3840-3851.
Contact the Crother Lab
8700 Beverly Blvd.
Davis Building, Room 4025
Los Angeles, CA 90048