Research Areas
The Di Vizio Laboratory was the first to demonstrate that fast migrating and metastatic amoeboid cancer cells undergoing non-apoptotic membrane blebbing can shed bioactive extracellular vesicles (EVs), namely large oncosomes, into the extracellular space due to their atypically large size in comparison with other classes of EVs.
Specific areas of study include:
- The role of large oncosomes in intercellular communication and in tumor growth and metastasis in solid tumors
- Molecular profiling of large oncosomes and other cancer-derived EVs by next generation sequencing and proteomics
- Molecular mechanisms and functional consequences of the internalization of large oncosomes in recipient cells
- Functional characterization of large oncosome-encapsulated mitochondria
- Identification of biomarkers using liquid biopsy
Contact the Di Vizio Lab
110 N George Burns Rd.,
Davis Building, Room 5094A
Los Angeles, CA 90048