Myeloid Cell Differentiation and Function
Hematopoietic stem cells (HSCs) give rise to all the different types of blood cells, including myeloid phagocytes (neutrophils, monocytes, macrophages and dendritic cells). Myeloid phagocytes are immune cells that defend the body against invading microbes, and also play important roles in inflammatory diseases, aging and cancer. The Goodridge Laboratory is studying the development (a process known as myelopoiesis) and function of myeloid phagocytes.
The Goodridge Laboratory is affiliated with the Cedars-Sinai Board of Governors Regenerative Medicine Institute, Department of Biomedical Sciences, Immunology & Infectious Diseases Research, Department of Medicine, F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute and Samuel Oschin Comprehensive Cancer Institute. The lab has received funding from the National Institutes of Health, American Heart Association, American Association of Immunologists, American Society of Hematology, and Cedars-Sinai (Board of Governors Regenerative Medicine Institute and Samuel Oschin Comprehensive Cancer Institute).
The Goodridge Laboratory studies include pathways and mechanisms of myelopoiesis during homeostasis and in response to infections and tumors. My lab also has interests in the roles of hematopoietic cells in tissue aging and neurodegenerative disease, as well as the use of induced pluripotent stem cell-derived myeloid cells to study and treat human disease.
Helen Goodridge, PhD
The Goodridge Laboratory studies the development and function of neutrophils, monocytes, macrophages and dendritic cells. These innate immune cells play key roles in anti-microbial defense and inflammation, as well as in tissue development, repair and regeneration.
Meet Our Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Goodridge Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
The Goodridge Laboratory has an open position for a postdoc. To apply, please send a description of your interests together with your curriculum vitae to firstname.lastname@example.org or apply online for the Postdoctoral Scientist - Goodridge Lab position.
Das MM, Godoy M, Chen S, Moser VA, Avalos P, Roxas KM, Dang I, Yáñez A, Zhang W, Bresee C, Arditi M, Liu GY, Svendsen CN*, Goodridge HS*.
Commun Biol. 2019; 2:73.
Yáñez A, Ng MY, Hassanzadeh-Kiabi N, Goodridge HS.
Blood. 2015 Feb 26;125(9):1452-1459.
Yáñez A, Coetzee SG, Olsson A, Muench DE, Berman BP, Hazelett DJ, Salomonis N, Grimes HL, Goodridge HS.
Immunity. 2017 Nov 21; 47(5):890-902.
Contact the Goodridge Lab
8700 Beverly Blvd.
Advanced Health Sciences Pavilion, Eighth Floor
Los Angeles, CA 90048