Jefferies Lab

Personal Statement

My goal is to uncover the fundamental mechanisms that lead to the development of lupus and discover ways to use this knowledge to better treat and manage this debilitating disease. To achieve this, I have focused on establishing strong working collaborations with leading rheumatologists, both in the U.S. and Ireland who specialize in lupus research.

Caroline Jefferies, PhD

  • Understanding the Interferon Signaling Pathway in Lupus Neutrophils
  • Investigating Crosstalk Among Estrogen, RNA/DNA Sensing and IFN in the Immune Response in SLE
  • Neutrophils, Endoplasmic Reticulum Stress and Lung Disease

CREWHS: Call for Applications

The Center for Research in Women’s Health and Sex Differences (CREWHS) is calling for investigators to submit their research on women’s health or sex differences. Winners of the award will receive up to $50,000 (direct costs) for a year with a potential to extend for a second year.

Please submit your research application via email at by 5:00 p.m. on Friday, June 23, 2023. Winners will be notified in July.

Meet Our Team

Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Jefferies Laboratory, whose dedicated efforts lead to groundbreaking discoveries.

Smith S, Fernando T, Wu PW, Seo J, Ní Gabhann J, Piskareva O, McCarthy E, Howard D, O’Connell P, Conway R, Gallagher P, Molloy E, Stallings RL, Kearns G, Forbess L, Ishimori M, Venuturupalli S, Wallace D, Weisman M, Jefferies CA.

J Autoimmun. 2017 May;79:105-111.

McCarthy EM, Smith S, Lee RZ, Cunnane G, Doran MF, Donnelly S, Howard D, O'Connell P, Kearns G, Ní Gabhann J, Jefferies CA.

Rheumatology (Oxford). 2014 Sep;53(9):1586-1594.

Ní Gabhann J, Hams E, Smith S, Wynne C, Byrne JC, Brennan K, Spence S, Kissenpfennig A, Johnston JA, Fallon PG, Jefferies CA.

PLOS ONE. 2014 Jan 21;9(1):e85834.

Contact the Jefferies Lab

8700 Beverly Blvd.
Davis Building, Room 5094E
Los Angeles, CA 90048