COVID-19 (coronavirus)

Jefferies Lab

Personal Statement

My goal is to uncover the fundamental mechanisms that lead to the development of lupus and discover ways to use this knowledge to better treat and manage this debilitating disease. To achieve this, I have focused on establishing strong working collaborations with leading rheumatologists, both in the U.S. and Ireland who specialize in lupus research.


Caroline Jefferies, PhD

  • Understanding the Interferon Signaling Pathway in Lupus Neutrophils
  • Investigating Crosstalk Among Estrogen, RNA/DNA Sensing and IFN in the Immune Response in SLE
  • Neutrophils, Endoplasmic Reticulum Stress and Lung Disease

CREWHS: Call for Applications


The Center for Research in Women’s Health and Sex Differences (CREWHS) is calling for investigators to submit their research on women’s health or sex differences. Two winners will be chosen and receive $30,000 direct cost funding for a year. Winners will also present their research at the 3rd Annual CREWHS Symposium on Tuesday, October 8, 2021. Please submit your research application via email at groupwomenshealthresearchadmin@cshs.org.

Meet Our Team


Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Jefferies Laboratory, whose dedicated efforts lead to groundbreaking discoveries.

Smith S, Fernando T, Wu PW, Seo J, Ní Gabhann J, Piskareva O, McCarthy E, Howard D, O’Connell P, Conway R, Gallagher P, Molloy E, Stallings RL, Kearns G, Forbess L, Ishimori M, Venuturupalli S, Wallace D, Weisman M, Jefferies CA.

J Autoimmun. 2017 May;79:105-111.

McCarthy EM, Smith S, Lee RZ, Cunnane G, Doran MF, Donnelly S, Howard D, O'Connell P, Kearns G, Ní Gabhann J, Jefferies CA.

Rheumatology (Oxford). 2014 Sep;53(9):1586-1594.

Ní Gabhann J, Hams E, Smith S, Wynne C, Byrne JC, Brennan K, Spence S, Kissenpfennig A, Johnston JA, Fallon PG, Jefferies CA.

PLOS ONE. 2014 Jan 21;9(1):e85834.

Contact the Jefferies Lab

8700 Beverly Blvd.
Davis Building, Room 5094E
Los Angeles, CA 90048

Fax:310-423-6898