Koronyo-Hamaoui Lab

The primary focus of the Koronyo-Hamaoui Laboratory is on early diagnosis and immune-based therapies for Alzheimer's disease (AD). A feasible noninvasive test to identify patients early on, which is essential for effective treatment, is an urgent unmet need. The Koronyo-Hamaoui Laboratory has shown, for the first time, that the hallmark pathology of AD, amyloid-β protein (Aβ) plaque, is present in the retina of human patients beginning at early stages. Furthermore, a unique approach has been developed in this lab to detect plaques in the retina of live rodent models by a noninvasive optical retinal imaging. This innovation unveils new possibilities for investigation of Alzheimer's pathology in the retina. It may also facilitate early diagnosis and noninvasive monitoring of disease progression.

First Identification and Noninvasive Imaging of Pathological Hallmarks of AD: Aβ Plaques in the Retina

Top panels: The Koronyo-Hamaoui team has discovered the characteristic signs of Alzheimer’s disease in postmortem retinae of AD patients, including early-stage cases. Bottom panels: The lab has developed the first noninvasive high-resolution Aβ-plaque retinal imaging in living subjects. (Koronyo et al. JCI Insight 2017)


Meet Our Team

Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Koronyo-Hamaoui Laboratory, whose dedicated efforts lead to groundbreaking discoveries.

Koronyo Y, Rentsendorj A, Mirzaei N, Regis GC, Sheyn J, Shi H, Barron E, Cook-Wiens G, Rodriguez AR, Koronyo-Hamaoui M, et al.

Acta Neuropathol. 2023 Apr;145(4):409-438. doi: 10.1007/s00401-023-02548-2. Epub 2023 Feb 11.

Shi H, Yin Z, Koronyo Y, Fuchs DT, Sheyn J, Davis MR, Wilson JW, Margeta MA, Pitts KM, Koronyo-Hamaoui M, et al.

Acta Neuropathol Commun. 2022 Sep 8;10(1):136. doi: 10.1186/s40478-022-01439-z.

Shi H, Koronyo Y, Rentsendorj A, Regis GC, Sheyn J, Fuchs DT, Kramerov AA, Ljubimov AV, Dumitrascu OM, Koronyo-Hamaoui M, et al.

Acta Neuropathol. 2020 May;139(5):813-836. doi: 10.1007/s00401-020-02134-w. Epub 2020 Feb 10.

Du X, Koronyo Y, Mirzaei N, Yang C, Fuchs DT, Black KL, Koronyo-Hamaoui M, Gao L.

PNAS Nexus. 2022 Aug 19;1(4):pgac164. doi: 10.1093/pnasnexus/pgac164.

Contact the Koronyo-Hamaoui Lab

Cedars-Sinai Maxine Dunitz Neurosurgical Institute
127 S. San Vicente Blvd.
Advanced Health Science Pavilion, Sixth Floor, Suite A6212
Los Angeles, CA 90048