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Lu Lab

Personal Statement

I am a physician scientist engaged in teaching, clinical work and basic research. I have been working in the fields of S-adenosylmethionine (SAMe) and glutathione (GSH) metabolism for more than 25 years and have received uninterrupted funding from the National Institutes of Health (NIH) since 1992."

Shelly C. Lu, MD

The Lu Laboratory has five active research programs funded by the National Institutes of Health. The longest-running program in the Lu Lab focuses on the regulation of hepatic glutathione (GSH) synthesis. GSH is vital in defense against oxidative stress. For more than 20 years, the Lu Laboratory has shown how the GSH synthetic enzymes are regulated transcriptionally and posttranscriptionally.


Meet Our Team

Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Lu Laboratory, whose dedicated efforts lead to groundbreaking discoveries.

Yang JW, Murray B, Barbier-Torres L, Liu T, Liu Z, Yang H, Fan W, Wang J, Li Y, Seki E, Mato JM, Lu SC

J Biol Chem. 2018 Dec 6. pii: jbc.RA118.004863.

Liu T, Yang H, Fan W, Tu J, Li TWH, Wang J, Shen H, Yang J, Xiong T, Steggerda J, Liu Z, Noureddin M, Maldonado SS, Annamalai A, Seki E, Mato JM, Lu SC.

Gastroenterology. 2018 Aug;155(2):557-571.e14. 

Fan W, Yang H, Liu T, Wang J, Li TW, Mavila N, Tang Y, Yang J, Peng H, Tu J, Annamalai A, Noureddin M, Krishnan A,Gores GJ, Martínez-Chantar ML, Mato JM, Lu SC.

Hepatology. 2017 Apr;65(4):1249-1266.