The McGovern Laboratory studies the effects of genetic variation in the inflammatory bowel diseases (IBD). Also called the Translational Genomics Group (TGG), the McGovern Lab is focused on identifying genetic variants associated with both Crohn's disease and ulcerative colitis and then investigating their functional effects and also their role in determining disease behavior and natural history, including response to therapy. In addition to gene discovery in Northern European ancestry populations, the McGovern Lab focuses on gene discovery in African-American, Hispanic, Ashkenazi Jewish and East Asian populations. These studies are designed, in part, to discover new therapies for IBD as well as to enhance our ability to apply a personalized approach to managing our patients in the clinic and to ensure that all populations benefit from these advances. The McGovern Lab also investigates the role of the microbiome in IBD and particularly the relationship between genetic variation in the host (human) and microbiome-related changes. The TGG is an integral part of the National Institute of Diabetes and Digestive and Kidney Diseases and International IBD Genetics Consortia as well as a member of the Crohn's & Colitis Foundation Microbiome Initiative and The Human Microbiome Project 2. Work in the McGovern Laboratory includes significant statistical and computational biology components, and the lab is developing novel methods for integrating multi-omic datasets together with clinical metadata.
The McGovern Laboratory is affiliated with the Cedars-Sinai F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, the Department of Medicine, and Precision Health.
Currently, I am professor of medicine, director of translational medicine, co-director of the Mucosal Immunology Repository for Inflammatory and Digestive Diseases biobank, director of Precision Health for Cedars-Sinai and the Joshua L. and Lisa Z. Greer Chair in Inflammatory Bowel Disease Genetics at Cedars-Sinai. I joined Cedars-Sinai in 2007 after completing my clinical training and my doctorate at the University of Oxford, UK."
Dermot P. McGovern, MD, PhD
The McGovern Laboratory, or Translational Genomics Group (TGG), is involved in studies to identify additional susceptibility genes in European populations as well as to identify genes associated with inflammatory bowel diseases (IBD) in the Puerto Rican, Asian, Ashkenazi Jewish and African American populations. The identification of these genes leads to a greater understanding of the underlying processes and causes that lead to IBD.
- Crohn's and Colitis Foundation of America (CCFA)
- European Union — FP7 mechanism
- The Leona M. and Harry B. Helmsley Charitable Trust
- National Institute of Health (NIDDK, NIAID)
Meet Our Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the McGovern Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Brant SR, Okou DT, Simpson CL, Cutler DJ, Haritunians T, Bradfield JP, Chopra P, Prince J, Begum F, Kumar A, Huang C, Venkateswaran S, Datta LW, Wei Z, Thomas K, Herrinton LJ, Klapproth JA, Quiros AJ, Seminerio J, Liu Z, Alexander JS, Baldassano RN, Dudley-Brown S, Cross RK, Dassopoulos T, Denson LA, Dhere TA, Dryden GW, Hanson JS, Hou JK, Hussain SZ, Hyams JS, Isaacs KL, Kader H, Kappelman MD, Katz J, Kellermayer R, Kirschner BS, Kuemmerle JF, Kwon JH, Lazarev M, Li E, Mack D, Mannon P, Moulton DE, Newberry RD, Osuntokun BO, Patel AS, Saeed SA, Targan SR, Valentine JF, Wang MH, Zonca M, Rioux JD, Duerr RH, Silverberg MS, Cho JH, Hakonarson H, Zwick ME, McGovern DP, Kugathasan S.
Gastroenterology. 2017 Jan;152(1):206-217.e2.
Yang SK, Hong M, Oh H, Low HQ, Jung S, Ahn S, Kim Y, Baek J, Lee CH, Kim E, Kim KM, Ye BD, Kim KJ, Park SH, Lee HS, Lee I, Shin HD, Han B, McGovern DP, et al.
Gastroenterology. 2016 Dec;151(6):1096-1099.e4.
Siegel CA, Whitman CB, Spiegel BM, Feagan B, Sands B, Loftus EV, Panaccione R, D'Haens G, Bernstein CN, Gearry R, Ng SC, Mantzaris GJ, Sartor B, Silverberg MS, Riddell R, Koutroubakis IE, O'Morain C, Lakatos PL, McGovern DP, et al.
Gut. First published online 2016 Oct 25.
Contact the McGovern Lab
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