Mun Lab
The Mun Laboratory focuses on developing patient-derived organs-on-chips and bioengineered 3D organs as in vitro models mimicking in vivo structures to understand the physiology and pathophysiology of mucociliary clearance in cystic fibrosis (CF) patients. Using 3D bioprinting technology, the Mun Lab has successfully developed a 3D human lung airway composed of lung fibroblasts with complex networks of differentiated lung airway epithelial cells, including ciliary cells and goblet cells. Bioengineered cell culture models help monitor cellular function and cell-cell interaction, allowing researchers to screen drugs and test drug toxicity for drug discovery. The Mun Lab also developed a novel in vitro co-culturing model, pancreas-on-a-chip, to study cystic fibrosis-related diabetes (CFRD)—one of the most typical and fatal complications in CF patients. The Mun Lab is located within the Division of Pulmonary and Critical Care Medicine in the Department of Medicine and affiliated with the Board of Governors Regenerative Medicine Institute.
Personal Statement
I obtained my PhD in the College of Engineering and Applied Science at the University of Cincinnati in 2016. I then completed my postdoctoral fellowship in the Department of Pulmonary Medicine at Cincinnati Children’s Hospital Medical Center, gaining extensive experience in designing and fabricating microfluidic-based organs-on-chips.
Kyu Shik Mun, PhD
Current research in the Mun Laboratory focuses on developing novel organs-on-chips using a 3D printer and/or photolithography and patient-specific 3D organ models using a 3D bioprinter. The Mun Lab has also been developing biosensors on organs-on-chips by a screen-printing technique that helps to monitor cell function in real time.
Meet Our Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Mun Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Ogden HL, Kim H, Wikenheiser-Brokamp KA, Naren AP, Mun K.
Micromachines. 2021 Jun 25; 12(7): 747.
Mun K, Arora K, Huang Y, Yang F, Yarlagadda S, Ramananda Y, Abu-El-Haija M, Palermo JJ, Appakalai BN, Nathan JD, et al.
Nat Commun. 2019 Jul 16; 10(1): 3124.
Huang Y, Arora K, Mun K, Yang F, Moon C, Yarlagadda S, Jegga A, Weaver T, Naren AP.
Sci Rep. 2019 Jul 8; 9(1):9808.
Contact the Mun Lab
127 S. San Vicente Blvd.
Pavilion, Suite 9200
Los Angeles, CA 90048