The Rutishauser Laboratory at Cedars-Sinai is investigating the neural mechanisms of learning, memory and decision-making level of single neurons and networks thereof. We are a systems neuroscience laboratory and use a combination of in-vivo, single-unit electrophysiology in humans, intracranial electrocorticography, eye tracking, electrical stimulation, behavior and computational, and theoretical approaches. We have helped pioneer the technique of human single-neuron recordings and continue to advance the tools, methods and surgical techniques that allow such experiments. The Rutishauser Laboratory has an ongoing close collaboration with scientists at the California Institute of Technology.
Our overarching goal is to capitalize on special neurosurgical situations to advance knowledge of the human nervous system. Our work is only possible because of a close collaboration between quantitative and experimental neuroscientists, neurologists and neurosurgeons—combining science and medicine.
Work in the Rutishauser Laboratory is made possible by funding provided by the National Science Foundation, National Institutes of Health, Brain & Behavior Research Foundation and the McKnight Endowment Fund for Neuroscience.
The Rutishauser Laboratory is located in the Department of Neurosurgery and the Maxine Dunitz Neurosurgical Institute and is also affiliated with the Neurology Department, the Center for Neural Science and Medicine, and the Department of Biomedical Sciences.
- Learning and Memory
- Social Cognition
- Decision Making
- Methods Development
Collaborations & Resources
- Ralph Adolphs Laboratory, California Institute of Technology
- Richard Andersen Laboratory, California Institute of Technology
- Computation & Neural Systems Program, California Institute of Technology
- Katalin Gothard Laboratory, University of Arizona, Tucson
- Wolfram Schultz Laboratory, University of Cambridge
- Doris Tsao Laboratory, California Institute of Technology
- John O'Doherty Laboratory, California Institute of Technology
- Shuo Wang, Washington University in St. Louis
Software tools that we provide:
- OSort – spike sorting software package
- StimOMatic – closed-looped stimulus control
- NlxToMat – import of neurophysiology data into Matlab
Datasets we provide:
Meet Our Team
Learn more about the scientists and physicians of the Rutishauser Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Mosher CP, Mamelak AN, Malekmohammadi M, Pouratian N, Rutishauser U.
Neuron. 2021 Mar 3;109(5):869-881.e6.
Minxha J, Adolphs R, Fusi S, Mamelak AN, Rutishauser U.
Science. 2020 Jun 26;368(6498):eaba3313.
Fu Z, Wu DJ, Ross I, Chung JM, Mamelak AN, Adolphs R, Rutishauser U.
Neuron. 2019 Jan 2;101(1):165-177.
Kamiński J, Mamelak AN, Birch K, Mosher CP, Tagliati M, Rutishauser U.
Curr Biol. 2018 May 7;28(9):1333-1343.
Contact the Rutishauser Lab
127 S. San Vicente Blvd.
Advanced Health Sciences Pavilion, 8th Floor
Los Angeles, CA 90048