I have a long-standing interest at the intersection of stem cell biology and cardiovascular biology, focusing on ways to effectively model diseases in a dish. In particular, I am excited by the prospect of making in vitro biology as close as possible to the in vivo. Recent developments in technologies that can intersect with stem cell biology, such as CRISPR/Cas9 and organ-chips, can help take in vitro disease modeling to the next level. Outside of the lab, I am also an advocate for effectively communicating science to general and scientific audiences through public speaking, while mentoring junior scientists at Cedars-Sinai and beyond.”
- Using stem cell-derived cardiovascular cells for modeling chemotherapy-induced cardiovascular toxicity
- Developing multicell lineage in vitro platforms such as cardiovascular organ-chips and cardiac organoids for studying cardiovascular diseases in a dish
- Studying the effects of microgravity and spaceflight on human tissues using stem cell-derived cells as a model and for biomanufacturing purposes
Meet Our Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Sharma Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Science. 2020 Mar 13;367(6483):1206
Sharma A, Sances S, Workman MJ, Svendsen CN.
Cell Stem Cell. 2020 Mar 5;26(3):309-329.
Sharma A, Burridge PW, McKeithan WL, Serrano R, Shukla P, Sayed N, Churko JM, Kitani T, Wu H, Holmström A, Matsa E, Zhang Y, Kumar A, Fan AC, Del Álamo JC, Wu SM, Moslehi JJ, Mercola M, Wu JC.
Sci Transl Med. 2017 Feb 15;9(377):eaaf2584.
Sharma A, Garcia G Jr, Wang Y, Plummer JT, Morizono K, Arumugaswami V, Svendsen CN.
Cell Rep Med. 2020 Jul 21;1(4):100052.