The research goals of the Shimada Laboratory are to determine the crosstalks of damage DNA response and inflammation, as well as oxidative stress and senescence in diseases progress. The Shimada Lab investigates the role of autophagy/mitophagy and IL-1 signaling in lipopolysaccharide plus ventilator induced acute lung injury, and the role of protein citrullination in Kawasaki disease vasculitis. Long term, the Shimada Lab will leverage this knowledge and findings to develop novel therapies and interventions.
The Shimada Laboratory is affiliated with the Infectious and Immunologic Diseases Research Center, Department of Biomedical Sciences and the Pediatrics Department.
Kenichi Shimada, PhD, has diverse scientific training in microbiology, immunology, molecular biology, lipid biochemistry and host-pathogen interactions. He completed his PhD studying how glycolipids of mycobacterium modulates the pathogenesis of mycobacterium infection and host responses. His postdoctoral research investigated the role of intracellular pathogen associated molecular patterns, Nod1/Nod2 and RIP2 in Chlamydia pneumoniae airway infection in the Arditi Laboratory. Shimada’s Chlamydia infection studies led to his recent seminal finding that oxidative mitochondrial DNA activates NLRP3 inflammasome. Research in the Shimada Lab is supported by NIH grants.
Kenichi Shimada, PhD
Meet Our Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Shimada Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Martinon D, Borges VF, Gomez AC, Shimada K.
Front Immunol. 2020 Jul 7;11:1623.
Nosaka N, Martinon D, Moreira D, Crother TR, Arditi M, Shimada K.
Front Immunol. 2020 Feb 14;11:207.
Noval Rivas M, Wakita D, Franklin MK, Carvalho TT, Abolhesn A, Gomez AC, Fishbein MC, Chen S, Lehman TJ, Sato K, Shibuya A, Fasano A, Kiyono H, Abe M, Tatsumoto N, Yamashita M, Crother TR, Shimada K, Arditi M.
Immunity. 2019 Sep 17;51(3):508-521.e6.
Contact the Shimada Lab
8700 Beverly Blvd.
Davis Building, Room 4008
Los Angeles, CA 90048