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Stehlik & Dorfleutner Lab

Personal Statement

"The Stehlik and Dorfleutner Laboratory utilizes leading-edge molecular, cellular and in vivo approaches for research in the field of molecular innate immunology with the goal to elucidate novel immune-regulatory mechanisms to advance our understanding of human immunity, and to identify novel targets for developing future therapies."


  • Discovery and functional characterization of the PYRIN domain-only protein family of human inflammasome inhibitors and their role in ameliorating inflammatory disease
  • Identification of the human NLRP7 inflammasome
  • Discovery of non-canonical inflammasome regulation
  • Tonic type I interferon-mediated maintenance of intestinal homeostasis and microbial diversity
Meet Our Team

Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Stehlik and Dorfleutner Laboratory, whose dedicated efforts lead to groundbreaking discoveries.

Chu HL, Indramohan M, Ratsaimandresy RA, Gangopadhyay A, Morris EP, Monack DM, Dorfleutner A*, Stehlik C*.

Nat Commun. 2018 Mar 8;9(1):996.

de Almeida L, Khare S, Misharin AV, Patel R, Wallin M, Perlman HR, Greaves DR, Hoffman HM, Dorfleutner A*, Stehlik C*.

Immunity. 2015 Aug 18;43(2):264-276.

Khare S, Ratsimandresy RA, de Almeida L, Cuda CM, Rellick SL, Misharin AV, Wallin MC, Gangopadhyay A, Forte E, Gottwein E, Perlman H, Reed JC, Greaves DR, Dorfleutner A*, Stehlik C*.

Nat Immunol. 2014 Apr;15(4):343-353.

Khare S, Dorfleutner A, Bryan NB, Yun C, Radian AD, de Almeida L, Rojanasakul Y, Stehlik C.

Immunity. 2012 Mar 23;36(3):464-476.

Contact the Stehlik & Dorfleutner Lab

127 S. San Vicente Blvd.
Pavilion, Room A-8700
Los Angeles, CA 90048

Christian Stehlik, PhD
Andrea Dorfleutner, PhD