Sutterwala & Cassel Lab
The Sutterwala and Cassel Laboratory is a lab led jointly by Fayyaz Sutterwala, MD, PhD, director of the Infectious Diseases Division, and Suzanne Cassel, MD, associate professor in Pulmonary and Critical Care. The focus of studies in the Sutterwala and Cassel Lab is a family of cytosolic molecules called nucleotide-binding domain leucine-rich repeat containing receptors (NLRs) that are involved in the regulation of innate immune responses and cell death pathways.
Some NLR family members promote the activation of pro-inflammatory caspases within multiprotein complexes called inflammasomes. Mutations within NLRP3, a member of the NLR family, have been linked to a group of autoinflammatory disorders in humans collectively known as the cryopyrin-associated periodic syndromes. NLRC4, another NLR family member, has been shown to play a crucial role in response to infection with a number of gram-negative bacteria. To understand the role of NLRs in coordinating the immune response, we have used a gene-targeting approach utilizing mice deficient in specific inflammasome components. The Sutterwala and Cassel Lab is interested in defining the molecular mechanisms by which inflammasomes are activated and their role in host defense against a variety of pathogens. The lab is also interested in how inflammasomes can exacerbate inflammatory responses to sterile inflammatory insults such as ischemia, as well as inhaled environmental pollutants.
The Sutterwala and Cassel Laboratory is affiliated with the Cedars-Sinai Lung Institute and the Infectious and Immunologic Diseases Research Center.
Aberrant activation of the NLRP3 inflammasome is pathological in many acute and chronic inflammatory diseases, including atherosclerosis, Alzheimer’s disease, pulmonary fibrosis and diabetes, and increasingly is being targeted as a potential therapy for these syndromes. As yet, however, not enough is known about exactly how the NLRP3 inflammasome assembles and becomes activated to devise specific interventions.
Meet Our Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Sutterwala and Cassel Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Elliott EI, MillerAN, BanothB, IyerSI, Stotland A, Weiss JP, Gottlieb RA, Sutterwala FS*, Cassel SL*.
J Immunol. 2018 May;200(9):3027-3052.
Hornick EE, Banoth B, Miller AM, Zacharias ZR, Jain N, Wilson ME, Gibson-Corley KN, Legge KL, Bishop GA, Sutterwala FS*, Cassel SL*.
J Immunol. 2018 Feb 1;200(3):1188-1197.
Ulland TK, Jain N, Hornick EE, Elliott EI, ClayGC, Sadler JJ, Mills KAM, Janowski AM, Volk APD, WangK, Legge KL, GakharL, BourdiM, Ferguson PJ, WilsonME, Cassel SL*, Sutterwala FS*.
Nat Commun. 2016 Oct 25;7:13180.
Contact the Sutterwala & Cassel Lab
Pavilion, Room A9402
127 S. San Vicente Blvd.
Los Angeles, CA 90048