Vujkovic-Cvijin Lab
The Vujkovic-Cvijin Laboratory investigates how human gut microbes influence inflammatory diseases. Research in the lab is focused on integration of omics technologies and lies at the intersection of immunology, microbiology and computational biology.
Personal Statement
The gut microbiota—the community of bacteria, fungi, viruses and protists that inhabit our intestines—has a profound impact on the way our body functions. The primary goal of my lab is to better understand how these microbes affect us, and to harness that relationship for improving human health. We use microbiology, immunology, ecology and data science techniques to identify microbes that spur inflammation, and in turn, devise ways of therapeutically targeting them for clinical benefit.
Ivan Vujkovic-Cvijin, PhD
Breakthrough Research Areas
- Identifying inflammatory gut microbes—We leverage the human antibody repertoire to identify microbes that may play causal roles in diseases including inflammatory bowel disease, arthritis, nonalcoholic steatohepatitis, and others.
- Precision microbiome editing—A major challenge in translating microbiome science to the clinic is the lack of tools to safely and effectively modulate the gut microbiome. We use data science and biostatistics to identify compounds capable of modulating the gut microbiota.
- Multi-omics integration—We use high-resolution profiling of the human immune system and the human microbiome to better understand how these two complex systems impact each other.
Meet Our Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Vujkovic-Cvijin Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Publications
Vujkovic-Cvijin I, Welles HC, Ha CWY, Huq L, Mistry S, Brenchley JM, Trinchieri G, Devkota S, Belkaid Y.
Sci Transl Med. 2022 Aug 17;14(658):eabl3927.
Vujkovic-Cvijin I, Sklar J, Jiang L, Natarajan L, Knight R, Belkaid Y.
Nature. 2020 Nov;587(7834):448-454.
Vujkovic-Cvijin I, Sortino O, Verheij E, Sklar J, Wit FW, Kootstra NA, Sellers B, Brenchley JM, Ananworanich J, Loeff MSV, Belkaid Y, Reiss P, Sereti I.
Nat Commun. 2020 May 15;11(1):2448.
Vujkovic-Cvijin I, Rutishauser RL, Pao M, Hunt PW, Lynch SV, McCune JM, Somsouk M.
Gut Microbes. 2017 Sep 3;8(5):440-450.
Vujkovic-Cvijin I, Dunham RM, Iwai S, Maher MC, Albright RG, Broadhurst MJ, Hernandez RD, Lederman MM, Huang Y, Somsouk M, Deeks SG, Hunt PW, Lynch SV, McCune JM.
Sci Transl Med. 2013 Jul 10;5(193):193ra91.
Contact the Vujkovic-Cvijin Lab
Research Pavilion
110 George Burns Road, Suite 4011
Los Angeles, CA 90048