Guzman Lab
The Guzman Lab integrates neuropathology, brain banking and spatial transcriptomics to define disease-specific molecular programs in human brain disorders. By mapping regionally selective neuronal, glial and vascular responses, we uncover mechanisms of vulnerability across epilepsy and neurodegeneration and translate these findings into clinically meaningful disease subtypes.
Personal Statement
Our goal is to anchor molecular discovery in human tissue, using spatial omics to define how brain diseases selectively target neural circuits. By integrating pathology with advanced genomics, we aim to transform how neurological diseases are classified and understood.
Samuel J. Guzman, MD
Breakthrough Research
We define molecular subtypes of epilepsy and Alzheimer’s disease by integrating spatial transcriptomics with neuropathology to map region-specific vulnerability.
Funded Research
Our research is supported by NIH-funded studies focused on neurovascular dysfunction, Alzheimer’s disease and spatial omics-driven disease mechanisms.
Publications
Explore recent publications from the Guzman Lab spanning spatial transcriptomics, epilepsy, Alzheimer’s disease and translational neuropathology.
Job Opportunities
We are recruiting students, fellows and postdocs who are interested in spatial transcriptomics, brain banking and translational neuroscience.
Collaborations
The Guzman Lab collaborates across Cedars-Sinai and globally to integrate neuropathology, imaging and omics for human brain disease research.
- University of Colorado Anschutz
- USC ADRC
- UCI Center for Neural Circuit Mapping