Sheyn Lab
The Sheyn Laboratory focuses on the development of stem cell therapies for multiple musculoskeletal disorders caused by acute injuries and aging. Using gene editing, biomechanical forces and specific transcription factors, the Sheyn Lab seeks to direct stem cells toward skeletal tissue-specific cell types to support healing and to reverse degenerative and inflammatory processes. Our close interaction with Cedars-Sinai orthopaedic surgeons and Biomedical Imaging Research Institute allows the Sheyn Laboratory to develop relevant animal models and to test the differentiated stem cell therapies in vivo.
The Sheyn Laboratory is affiliated with the Cedars-Sinai Board of Governors Regenerative Medicine Institute and Orthopaedics, Surgery, and the Department of Biomedical Sciences.
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Personal Statement
I have devoted more than 15 years to the research of gene and stem cell therapies. This field holds great therapeutic potential. In my postdoctoral work, I developed an efficient and easily reproducible method to modify stem cells and to regenerate bone defects. The cell therapy approach was tested and found biomechanically valid and new bone tissue was comparable to the native bone."
Dmitriy Sheyn, PhD
- Intervertebral Disc Regeneration—Making the Intervertebral Disc Young Again
- Challenging Dogmas and Developing New Treatments in Sports Medicine
- Revitalization of Allografts—Bringing New Life to Dead Bone Grafts for Craniofacial Injuries
Collaborations
Internal
- Breunig Laboratory
- Di Vizio Laboratory
- Ho Laboratory
- Li Laboratory
- Orr Limpisvasti, MD, Kerlan-Jobe Institute
- Bert R. Mandelbaum, MD, Kerlan-Jobe Institute
- Jon Mallen-St. Clair, MD, PhD
- Metzger Laboratory
- Thomas J. Kremen, MD
- Tiffanny G. Perry, MD
- Sang Do Kim, MD, MS
External
- Denis Evseenko, MD, PhD, University of Southern California
- Karen Lyons, PhD
- Dror Seliktar, PhD, Technion Israel
- Jess Gerrit Snedeker, PhD, University of Zurich, Switzerland
- Laura S. Stone, PhD, University of Minnesota
- Mehmet R. Dokmeci, Associate Professor
Meet Our Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Sheyn Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Open Positions
Graduate Student
To apply for PhD studies in the Sheyn Lab, apply for admission to the graduate program in the Department of Biomedical Sciences and choose Dmitriy Sheyn, PhD, as your research rotation adviser.
Research Intern
The Sheyn Laboratory invites students to gain hands-on experience. The research intern will be instructed in lab safety and sterile techniques and trained to perform wet-lab techniques and image analysis.
Postdoctoral Scientist
The Sheyn Laboratory has a current opening for a Postdoctoral Scientist. This position will focus on IVD regeneration and stem cell differentiation projects.
Jiang W, Glaeser JD, Salehi K, Kaneda G, Mathkar P, Wagner A, Ho R, Sheyn D.
iScience. 2022 Jun 2;25(7):104504.
Glaeser JD, Behrens P, Stefanovic T, Salehi K, Papalamprou A, Tawackoli W, Metzger MF, Eberlein S, Nelson T, Arabi Y, Kim K, Baloh RH, Ben-David S, Cohn-Schwartz D, Ryu R, Bae HW, Gazit Z, Sheyn D.
Stem Cells Transl Med. 2021 May;10(5):797-809.
Chahla J, Papalamprou A, Chan V, Arabi Y, Salehi K, Nelson TJ, Limpisvasti O, Mandelbaum BR, Tawackoli W, Metzger MF, Sheyn D.
Arthroscopy. 2021 Jan;37(1):252-265.
Kremen TJ Jr, Stefanovic T, Tawackoli W, Salehi K, Avalos P, Reichel D, Perez MJ, Glaeser JD, Sheyn D.
Am J Sports Med. 2020 Oct;48(12):3002-3012.
Contact the Sheyn Lab
127 S. San Vicente Blvd.
Advanced Health Sciences Pavilion, A8308
Los Angeles, CA 90048