Sheyn Lab
The Sheyn Lab focuses on the development of stem cell therapies for multiple musculoskeletal disorders caused by acute injuries and aging. Using gene editing, biomechanical forces and specific transcription factors, the Sheyn Lab seeks to direct stem cells toward skeletal tissue-specific cell types to support healing and to reverse degenerative and inflammatory processes. Our close interaction with Cedars-Sinai orthopaedic surgeons and Biomedical Imaging Research Institute allows the Sheyn Lab to develop relevant animal models and to test the differentiated stem cell therapies in vivo.
The Sheyn Lab is affiliated with the Cedars-Sinai Board of Governors Regenerative Medicine Institute and Orthopaedics, Surgery, and the Department of Biomedical Sciences.
Personal Statement
I have devoted more than 15 years to the research of gene and stem cell therapies. This field holds great therapeutic potential. In my postdoctoral work, I developed an efficient and easily reproducible method to modify stem cells and to regenerate bone defects. The cell therapy approach was tested and found biomechanically valid and new bone tissue was comparable to the native bone."
Dmitriy Sheyn, PhD
Breakthrough Research
- Microgel-encapsulated stem cells to alleviate low back pain
- Studying the mechanisms of discogenic low back pain
- Developing stem cell therapies for tendon injuries
- Injectable human iPSC-derived macrophages as a potential preventive treatment for knee post- traumatic osteoarthritis (PTOA) in a rat model
Publications
Learn more about the recent research publications from the Sheyn Lab.
Laboratory Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Sheyn Lab, whose dedicated efforts lead to groundbreaking discoveries.
Job Opportunities
We are actively recruiting students and postdocs to be our colleagues and expand lab knowledge and expertise to make important breakthroughs.
Collaborations
The Sheyn Lab collaborates with a wide range of investigators within Cedars-Sinai and institutions around the world.
- Denis Evseenko, MD, PhD, University of Southern California
- Karen Lyons, PhD
- Dror Seliktar, PhD, Technion Israel
- Jess Gerrit Snedeker, PhD, University of Zurich, Switzerland
- Laura S. Stone, PhD, University of Minnesota
- Mehmet R. Dokmeci, Associate Professor
Contact the Sheyn Lab
127 S. San Vicente Blvd.
Advanced Health Sciences Pavilion, A8308
Los Angeles, CA 90048