Trauma Journal Club

Sept. 21, 2016

Police transport vs. ground EMS: A trauma system-level evaluation of prehospital care policies and their effect on clinical outcomes  

High-protein hypocaloric vs normocaloric enteral nutrition in critically ill patients: A randomized clinical trial  


Sept. 14, 2016

Nontrauma open abdomens: A prospective observational study  

Prehospital traumatic cardiac arrest: Management and outcomes from the resuscitation outcomes consortium epistry-trauma and PROPHET registries  

Resuscitative endovascular balloon occlusion of the aorta might be dangerous in patients with severe torso trauma: A propensity score analysis  


Sept. 7, 2016

A Multicenter, Randomized Clinical Trial of IV Iron Supplementation for Anemia of Traumatic Critical Illness  

Dexmedetomidine as an adjunct for sedation in patients with traumatic brain injury  

Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery - a randomised, double-blind, placebo-controlled trial  


Aug. 24, 2016

Assessment of Clinical Criteria for Sepsis For the Third International Consensus Definitions for Sepsis and Septic Shock  

The Prospective, Observational, Multicenter, Major Trauma Transfusion (PROMMTT) Study  

Intensive versus Conventional Glucose Control in Critically Ill Patients  


Aug. 17, 2016

Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit  

Nonoperative Management Is as Effective as Immediate Splenectomy for Adult Patients with High-Grade Blunt Splenic Injury  

Nutrition in the Acute Phase of Critical Illness  


Aug. 10, 2016

Methylene Blue: Magic Bullet for Vasoplegia?  

Methylene Blue is Associated With Poor Outcomes in Vasoplegic Shock  

Methylene Blue Reduces Mortality and Morbidity in Vasoplegic Patients After Cardiac Surgery  


Aug. 3, 2016

Percutaneously drained intra-abdominal infections do not require longer duration of antimicrobial therapy  

Suction evacuation of hemothorax: A prospective study  

The profile of wounding in civilian public mass shooting fatalities  


July 19, 2016

Association Between Enoxaparin Dosage Adjusted by Anti–Factor Xa Trough Level and Clinically Evident Venous Thromboembolism After Trauma  

Pragmatic Randomized Optimal Platelet and Plasma Ratios (PROPPR) Trial: Design, rationale and implementation  

Reducing acute kidney injury due to vancomycin in trauma patients  


July 13, 2016

Intravascular Complications of Central Venous Catheterization by Insertion Site  

How long should we fear? Long-term risk of venous thromboembolism in patients with traumatic brain injury  

Immediate total-body CT scanning versus conventional imaging and selective CT scanning in patients with severe trauma (REACT-2): a randomised controlled trial  


July 6, 2016

Dexmedetomidine for the Treatment of Hyperactive Delirium Refractory to Haloperidol in Nonintubated ICU Patients: A Nonrandomized Controlled Trial  

Initial safety and feasibility of cold-stored uncrossmatched whole blood transfusion in civilian trauma patients  

Long-Term Outcomes in Critically Ill Septic Patients Who Survived Cardiopulmonary Resuscitation  


June 22, 2016

Early antithrombotic therapy is safe and effective in patients with blunt cerebrovascular injury and solid organ injury or traumatic brain injury  

Evaluation of Cervical Spine Clearance by Computed Tomographic Scan Alone in Intoxicated Patients With Blunt Trauma  

Comparison of high-flow nasal oxygen therapy with conventional oxygen therapy and noninvasive ventilation in adult patients with acute hypoxemic respiratory failure: A meta-analysis and systematic review  


June 15, 2016

Comparative Effectiveness of Second Vasoactive Agents in Septic Shock Refractory to Norepinephrine  

Ultrasound-guided placement of midline catheters in the surgical intensive care unit: a cost-effective proposal for timely central line removal  

Smaller introducer sheaths for REBOA may be associated with fewer complications  


June 8, 2016

Effect of Noninvasive Ventilation Delivered by Helmet vs Face Mask on the Rate of Endotracheal Intubation in Patients With Acute Respiratory Distress Syndrome  

Intraoperative hypotensive resuscitation for patients undergoing laparotomy or thoracotomy for trauma: Early termination of a randomized prospective clinical trial  

Role of computed tomography angiography in the management of Zone II penetrating neck trauma in patients with clinical hard signs  


June 1, 2016

Early initiation of extracorporeal membrane oxygenation improves survival in adult trauma patients with severe acute respiratory distress syndrome  

Non-Operative Management Is As Effective As Immediate Splenectomy For Adult Patients with High-Grade Blunt Splenic Injury  

Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit  


May 18, 2016

Current management of hemorrhage from severe pelvic fractures: Results of an American Association for the Surgery of Trauma multi-institutional trial  

Relationship Between ICU Length of Stay and Long-Term Mortality for Elderly ICU Survivors  


May 11, 2016

Minimally invasive is maximally effective: Diagnostic and therapeutic laparoscopy for penetrating abdominal injuries  

Randomized Controlled Trial of Inhaled Nitric Oxide for the Treatment of Microcirculatory Dysfunction in Patients With Sepsis  

Surviving Sepsis Campaign: Association Between Performance Metrics and Outcomes in a 7.5-Year Study  


May 4, 2016

Embedding a Trauma Hospitalist in the Trauma Service Reduces Mortality and 30-Day Trauma-Related Readmissions  

Routine Chest Radiography Is Not Necessary After Ultrasound-Guided Right Internal Jugular Vein Catheterization  

The ‘‘Flipped Classroom’’ Model for Teaching in the Intensive Care Unit: Rationale, Practical Considerations, and an Example of Successful Implementation  


April 12, 2016

Effect of Postextubation High-FlowNasal Cannula vs Conventional Oxygen Therapy on Reintubation in Low-Risk Patients  

Effect of Noninvasive Ventilation on Tracheal Reintubation Among Patients With Hypoxemic Respiratory Failure Following Abdominal Surgery  


April 6, 2016

Preinjury warfarin, but not antiplatelet medications, increases mortality in elderly traumatic brain injury patients  

The Role of Aerosolized Colistin in the Treatment of Ventilator-Associated Pneumonia: A Systematic Review and Metaanalysis  

The effects of alcohol on coagulation in trauma patients: Interpreting thrombelastography with caution  


March 23, 2016

Factors Associated with Pulmonary Embolism Within 72 Hours of Admission after Trauma: A Multicenter Study  

Feasibility, utility, and safety of midodrine during recovery phase from septic shock  

Critical Care Resuscitation Unit: An Innovative Solution to Expedite Transfer of Patients with Time-Sensitive Critical Illness  


March 16, 2016

Defining Transfusion Triggers and Utilization of Fresh Frozen Plasma and Platelets Among Patients Undergoing Hepatopancreaticobiliary and Colorectal Surgery  

Evaluation of Noninvasive Hemoglobin Monitoring in Surgical Critical Care Patients  


March 9, 2016

The impact of tranexamic acid on mortality in injured patients with hyperfibrinolysis  

Multicenter evaluation of temporary intravascular shunt use in vascular trauma  

Fluid Management With a Simplified Conservative Protocol for the Acute Respiratory Distress Syndrome*  


March 2, 2016

Periprocedural nutrition in the intensive care unit: a pilot study  

The Efficacy of Earplugs as a Sleep Hygiene Strategy for Reducing Delirium in the ICU: A Systematic Review and Meta-Analysis  

Surveillance and Early Management of Deep Vein Thrombosis Decreases Rate of Pulmonary Embolism in High-Risk Trauma Patients  


Feb. 17, 2016

Stress-induced hyperglycemia is associated with higher mortality in severe traumatic brain injury  

Pneumomediastinum following blunt trauma: Worth an exhaustive workup?  

The Impact of Tracheostomy Timing on Clinical Outcome and Adverse Events in Poor-Grade Subarachnoid Hemorrhage*  


Feb. 10, 2016

The splenic injury outcomes trial: An American Association for the Surgery of Trauma multi-institutional study  

Multicenter Evaluation of Prolonged Empiric Antibiotic Therapy in Adult ICUs in the United States  


Feb. 2, 2016

Withdrawal of Life-Sustaining Therapy in Patients With Intracranial Hemorrhage: Self-Fulfilling Prophecy or Accurate Prediction of Outcome?  

TIMP2•IGFBP7 biomarker panel accurately predicts acute kidney injury in high-risk surgical patients  


Jan. 20, 2016

High-Protein Enteral Nutrition Enriched With Immune-Modulating Nutrients vs Standard High-Protein Enteral Nutrition and Nosocomial Infections in the ICU  

Association Between Helicopter vs Ground Emergency Medical Services and Survival for Adults With Major Trauma  

Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma  


Jan. 13, 2016

Thoracolumbar spine clearance: Clinical examination for patients with distracting injuries  

Resuscitative endovascular balloon occlusion of the aorta (REBOA): Comparison with immediate transfusion following massive hemorrhage in swine  

A new kid on the block: Outcomes with Kcentra 1 year after approval  


Jan. 6, 2016

Aspirin in Patients Undergoing Noncardiac Surgery  

Long-Term β-Blocker Therapy Decreases Blood Lactate Concentration in Severely Septic Patients  

Effects of Fluid Resuscitation With Colloids vs Crystalloids on Mortality in Critically Ill Patients Presenting With Hypovolemic Shock  


Dec. 23, 2015

VTE Incidence and Risk Factors in Patients With Severe Sepsis and Septic Shock  

Hemoglobin Level and Hospital Mortality Among ICU Patients With Cardiac Disease Who Received Transfusions  


Dec. 16, 2015

Fibrinolysis for Patients with Intermediate- Risk Pulmonary Embolism  

High-Frequency Oscillation in Early Acute Respiratory Distress Syndrome  


Dec. 2, 2015

Diuretic Strategies in Patients with Acute Decompensated Heart Failure  

Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome  

Dexmedetomidine vs Midazolam for Sedation of Critically Ill Patients A Randomized Trial  


Nov. 18, 2015

Systemic Inflammatory Response Syndrome Criteria in Defining Severe Sepsis  

Clinical and radiographic outcomes following traumatic Grade 1 and 2 carotid artery injuries  

Procalcitonin-guided antibiotic therapy for septic patients in the surgical intensive care unit  


Nov. 11, 2015

Intravascular Complications of Central Venous Catheterization by Insertion Site  


Nov. 4, 2015

Early v. late TPN in Critically Ill Adults  

The Surviving Sepsis Campaign bundles and outcome: results from the International Multicentre Prevalence Study on Sepsis (the IMPreSS study)  

Initial screening test for blunt cerebrovascular injury  


Oct. 21, 2015

Acetaminophen for Fever in Critically Ill Patients with Suspected Infection  

Impact of intravenous fluid composition on outcomes in patients with systemic inflammatory response syndrome  

Effect of Noninvasive Ventilation vs Oxygen Therapy on Mortality Among Immunocompromised Patients With Acute Respiratory Failure  


Oct. 14, 2015

Nutritional Status and Mortality in the Critically Ill  

Being Overweight Is Associated With Greater Survival in ICU Patients: Results From the Intensive Care Over Nations Audit  

A prospective analysis of urinary tract infections among elderly trauma patients  


Sept. 23, 2015

The contribution of opiate analgesics to the development of infectious complications in trauma patients  

Incidence and predictors of new-onset atrial fibrillation in noncardiac intensive care unit patients  

Clinical characteristics and outcomes of septic patients with new-onset atrial fibrillation  


Sept. 16, 2015

Transfusion of Cryopreserved Packed Red Blood Cells is Safe and Effective After Trauma  

Heparin versus enoxaparin for prevention of venous thromboembolism after trauma: A randomized noninferiority trial  

Decompressive Craniectomy in Diffuse Traumatic Brain Injury  


Sept. 2, 2015

A Trial of Intracranial-Pressure Monitoring in Traumatic Brain Injury  

Lower versus Higher Hemoglobin Threshold for Transfusion in Septic Shock  


Aug. 19, 2015

Characteristics of chest wall injuries that predict postrecovery pulmonary symptoms: A secondary analysis of data from a randomized trial

Enoxaparin ameliorates postYtraumatic brain injury edema and neurologic recovery, reducing cerebral leukocyte endothelial interactions and vessel permeability in vivo

Preventing Renal Failure in Patients with Rhabdomyolysis: Do Bicarbonate and Mannitol Make a Difference?


Aug. 12, 2015

A MULTICENTER, RANDOMIZED, CONTROLLED CLINICAL TRIAL OF TRANSFUSION REQUIREMENTS IN CRITICAL CARE

A Comparison of Albumin and Saline for Fluid Resuscitation in the Intensive Care Unit

Ventilation Strategy Using Low Tidal Volumes, Recruitment Maneuvers, and High Positive End-Expiratory Pressure for Acute Lung Injury and Acute Respiratory Distress Syndrome


Aug. 5, 2015

All the bang without the bucks: Defining essential point-of-care testing for traumatic coagulopathy

EARLY ENTERAL NUTRITION AND OUTCOMES OF CRITICALLY ILL PATIENTS TREATED WITH VASOPRESSORS AND MECHANICAL VENTILATION

Reversal Strategies for Vitamin K Antagonists in Acute Intracerebral Hemorrhage


July 22, 2015

Empiric Antibiotic Treatment Reduces Mortality in Severe Sepsis and Septic Shock From the First Hour: Results From a Guideline-Based Performance Improvement Program

Association of Hyperchloremia With Hospital Mortality in Critically Ill Septic Patients

The Impact of Timing of Antibiotics on Outcomes in Severe Sepsis and Septic Shock: A Systematic Review and Meta-Analysis


July 15, 2015

Protocols and Hospital Mortality in Critically Ill Patients: The United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study

Effects of Sigh on Regional Lung Strain and Ventilation Heterogeneity in Acute Respiratory Failure Patients Undergoing Assisted Mechanical Ventilation

Practice Patterns and Outcomes Associated With Choice of Initial Vasopressor Therapy for Septic Shock


July 8, 2015

Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients

Transient and Persistent Acute Kidney Injury and the Risk of Hospital Mortality in Critically Ill Patients: Results of a Multicenter Cohort Study

Age of Transfused Blood in Critically Ill Adults


July 1, 2015

High-flow nasal cannula oxygen therapy in adults

High-Flow Oxygen through Nasal Cannula in Acute Hypoxemic Respiratory Failure

Permissive Underfeeding or Standard Enteral Feeding in Critically Ill Adults


June 10, 2015

Open Abdomen with Concomitant Enteroatmospheric Fistula: Attempt to Rationalize the Approach to a Surgical Nightmare and Proposal of a Clinical Algorithm

National mandatory motorcycle helmet laws may save $2.2 billion annually: An inpatient and value of statistical life analysis

Lethal now or lethal later: The natural history of Grade 4 blunt cerebrovascular injury


May 20, 2015

Transient and Persistent Acute Kidney Injury and the Risk of Hospital Mortality in Critically Ill Patients: Results of a Multicenter Cohort Study

Does unit designation matter? A dedicated trauma intensive care unit is associated with lower postinjury complication rates and death after major complication


May 13, 2015

The Very Elderly Admitted to ICU: A Quality Finish?

Missed Central Venous Guide Wires: A Systematic Analysis of Published Case Reports

A Randomized Controlled Trial of Regional Citrate Versus Regional Heparin Anticoagulation for Continuous Renal Replacement Therapy in Critically Ill Adults


May 6, 2015

Secondary brain injury in trauma patients: The effects of remote ischemic conditioning

Intracranial pressure monitoring and inpatient mortality in severe traumatic brain injury: A propensity scoreYmatched analysis

Early autologous fresh whole blood transfusion leads to less allogeneic transfusions and is safe


April 22, 2015

Accuracy of Vigileo/Flotracmonitoring system in morbidly obese patients

Prospective observation of physical activity in critically ill patients who were intubated for more than 48 hours

High-Dose vs Non–High-Dose Proton Pump Inhibitors After Endoscopic Treatment in Patients With Bleeding Peptic Ulcer


April 15, 2015

Obesity and clotting: Body mass index independently contributes to hypercoagulability after injury

Does resuscitation with plasma increase the risk of venous thromboembolism?


April 8, 2015

Early versus Delayed Decompression for Traumatic Cervical Spinal Cord Injury: Results of the Surgical Timing in Acute Spinal Cord Injury Study

Functional Outcomes Following Trauma-Related Lower-Extremity Amputation

Effect of Surgical Treatment on Mortality After Acetabular Fracture in the Elderly: A Multicenter Study of 454 Patients


April 1, 2015

Age of Transfused Blood in Critically Ill Adults

Liberal or Restrictive Transfusion after Cardiac Surgery

Sensitivity of Plain Pelvis Radiography in Children With Blunt Torso Trauma


March 18, 2015

Detailed Description of All Deaths in Both the Shock and Traumatic Brain Injury Hypertonic Saline Trials of the Resuscitation Outcomes Consortium

Contemporary Bloodletting in Cardiac Surgical Care

Overuse of helicopter transport in the minimally injured: A health care system problem that should be corrected


March 11, 2015

Staging of acute diverticulitis based on clinical, radiologic, and physiologic parameters

A comparison of prehospital lactate and systolic blood pressure for predicting the need for resuscitative care in trauma transported by ground


March 4, 2015

Basic Critical Care Echocardiography by Pulmonary Fellows: Learning Trajectory and Prognostic Impact Using a Minimally Resourced Training Model

Prevention of Ventilator-Associated Pneumonia and Ventilator-Associated Conditions: A Randomized Controlled Trial With Subglottic Secretion Suctioning

Nonoperative management of hemodynamically unstable abdominal trauma patients with angioembolization and resuscitative endovascular balloon occlusion of the aorta


Feb. 18, 2015

The Effect of Incentive Spirometry on Postoperative Pulmonary Function Following Laparotomy A Randomized Clinical Trial

Clinical evidence of inflammation driving secondary brain injury: A systematic review


Feb. 11, 2015

Outcomes after emergency general surgery at teaching versus nonteaching hospitals

Transfusion Strategies for Acute Upper Gastrointestinal Bleeding

Albumin Replacement in Patients with Severe Sepsis or Septic Shock


Feb. 4, 2015 

A Trial of Intracranial-Pressure Monitoring in Traumatic Brain Injury

Long-term outcomes of ground-level falls in the elderly

Outpatient laparoscopic appendectomy should be the standard of care for uncomplicated appendicitis


Jan. 21, 2015

Preventing Renal Failure in Patients with Rhabdomyolysis: Do Bicarbonate and Mannitol Make a Difference?

Radiation fear: Impact on compliance with trauma imaging guidelines in the pregnant patient

Effect of a dalteparin prophylaxis protocol using anti-factor Xa concentrations on venous thromboembolism in high-risk trauma patients


Jan. 7, 2015

Preemptive Thoracic Drainage to Eradicate Postoperative Pulmonary Complications after Living Donor Liver Transplantation

Risk factors for delirium in older trauma patients admitted to the surgical intensive care unit

Adult respiratory distress syndrome risk factors for injured patients undergoing damage-control laparotomy: AAST multicenter post hoc analysis


Dec. 31, 2014

Prospective validation of the brain injury guidelines: Managing traumatic brain injury without neurosurgical consultation

Emergency tracheal intubation immediately following traumatic injury: An Eastern Association for the Surgery of Trauma practice management guideline


Dec. 17, 2014

Prospective validation of the brain injury guidelines: Managing traumatic brain injury without neurosurgical consultation

Introduction of Surgical Safety Checklists in Ontario, Canada

Western Trauma Association Critical Decisions in Trauma: Penetrating chest trauma


Dec. 10, 2014

Enteral Feeding Within Three Hours After Percutaneous Endoscopic Gastrostomy Placement

Effect of Erythropoietin and Transfusion Threshold on Neurological Recovery After Traumatic Brain Injury

Critical Illness–Related Corticosteroid Insufficiency in Cirrhotic Patients With Acute Gastroesophageal Variceal Bleeding: Risk Factors and Association With Outcome


Dec. 3, 2014

Successful placement of intracranial pressure monitors by trauma surgeons

Traumatic brain injury and A-blockers: Not all drugs are created equal


Nov. 19, 2014

Lower versus Higher Hemoglobin Threshold for Transfusion in Septic Shock

Selective Nonoperative Management in 1106 Patients With Abdominal Gunshot Wounds

Usefulness of Bowel Sound Auscultation: A Prospective Evaluation


Nov. 12, 2014

Screening for osteoporosis after trauma: A new approach using quantitative computed tomography of the skull

Rosuvastatin for Sepsis-Associated Acute Respiratory Distress Syndrome


Nov. 5, 2014

Isolated Free Fluid on Abdominal Computed Tomography in Blunt Trauma: Watch and Wait or Operate?


Oct. 22, 2014

Goal-Directed Resuscitation for Patients with Early Septic Shock

Prehospital hypertension is predictive of traumatic brain injury and is associated with higher mortality

Early repeat imaging is not warranted for high-grade blunt cerebrovascular injuries


Oct. 15, 2014

Time to first take-back operationpredicts successful primary fascial closure in patients undergoing damage control laparotomy

Trial of the Route of Early Nutritional Support in Critically Ill Adults


Oct. 8, 2014

Pan computed tomography versus selective computed tomography in stable, young adults after blunt trauma with moderate mechanism: A cost-utility analysis

Computed tomographic scan: It’s not just about the fracture


Oct. 1, 2014

Unconscious race and class bias: Its association with decision making by trauma and acute care surgeons

Survival of pediatric blunt trauma patients presenting with no signs of life in the field

Impact of Plasma Transfusion in Trauma Patients Who Do Not Require Massive Transfusion

Whole-body computed tomographic scanning leads to better survival as opposed to selective scanning in trauma patients: A systematic review and meta-analysis


Sept. 17, 2014

Attribution: Whose complication is it?

Time matters in 1:1 resuscitations: Concurrent administration of blood:plasma and risk of death

Evidence-based protocol for prophylactic antibiotics in open fractures: Improved antibiotic stewardship with no increase in infection rates


Sept. 10, 2014

Worse outcomes among uninsured general surgery patients: Does the need for an emergency operation explain these disparities?

Compliance with Recommended Care at Trauma Centers: Association with Patient Outcomes


Sept. 3, 2014

The significance of platelet count in traumatic brain injury patients on antiplatelet therapy

Below-knee deep vein thrombosis: An opportunity to prevent pulmonary embolism?


Aug. 13, 2014

Effects of Fluid Resuscitation With Colloids vs Crystalloids on Mortality in Critically Ill Patients Presenting With Hypovolemic Shock

Vancomycin-Associated Nephrotoxicity in the Critically Ill: A Retrospective Multivariate Regression Analysis

Patience Is a Virtue: An Argument for Delayed Surgical Intervention in Fulminant Clostridium difficile Colitis


Aug. 6, 2014

Trauma remains a surgical disease from cradle to grave

Negative pleural suction in thoracic trauma patients: A randomized controlled trial

Computed tomography scans with intravenous contrast: Low incidence of contrast-induced nephropathy in blunt trauma patients


July 30, 2014

Early propranolol administration to severely injured patients can improve bone marrow dysfunction

Intra-abdominal injury following blunt trauma becomes clinically apparent within 9 hours

Improving organ donation rates by modifying the family approach process


July 23, 2014

Frailty in surgery

Prevalence and impact of frailty on mortality in elderly ICU patients: a prospective, multicenter, observational study

Dying with Dignity in the Intensive Care Unit


July 16, 2014

Venovenous extracorporeal life support improves survival in adult trauma patients with acute hypoxemic respiratory failure: A multicenter retrospective cohort study

Obesity and vehicle type as risk factors for injury caused by motor vehicle collision

Flail chest injuries: A review of outcomes and treatment practices from the National Trauma Data Bank


July 9, 2014

Standard laparoscopic trocars for the treatment of tension pneumothorax: A superior alternative to needle decompression

Unveiling posttraumatic stress disorder in trauma surgeons: A national survey

Using the Rothman index to predict early unplanned surgical intensive care unit readmissions


July 2, 2014

EFFECT OF PRONE POSITIONING ON THE SURVIVAL OF PATIENTS WITH ACUTE RESPIRATORY FAILURE

Prone Positioning in Patients With Moderate and SevereAcute RespiratoryDistress Syndrome

Prone Positioning in Severe Acute Respiratory Distress Syndrome


June 25, 2014

Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial

A Comparison of Albumin and Saline for Fluid Resuscitation in the Intensive Care Unit


June 19, 2014

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012

The Interaction of Vasopressin and Corticosteroids in Septic Shock: A Pilot Randomized Controlled Trial*

Conservative Oxygen Therapy in Mechanically Ventilated Patients: A Pilot Before-and-After Trial*


June 11, 2014

Can words hurt? Patient–provider interactions during invasive procedures

The case of the disappearing teaspoons: longitudinal cohort study of the displacement of teaspoons in an Australian research institute

Can shoe size predict penile length?


June 4, 2014

Arterial Catheters as a Source of Bloodstream Infection: A Systematic Review and Meta-Analysis*


May 28, 2014

A Randomized Trial of Diagnostic Techniques for Ventilator-Associated Pneumonia

Prospective Comparison of Bronchoalveolar Lavage and Quantitative Deep Tracheal Aspirate in the Diagnosis of Ventilator Associated Pneumonia

A Prospective Assessment of Diagnostic Efficacy of Blind Protective Bronchial Brushings Compared to Bronchoscope-Assisted Lavage, Bronchoscope-Directed Brushings, and Blind Endotracheal Aspirates in Ventilator-Associated Pneumonia


May 14, 2014

Effect of a Lung Protective Strategy for Organ Donors on Eligibility and Availability of Lungs for Transplantation

Methylprednisolone Therapy in Deceased Donors Reduces Inflammation in the Donor Liver and Improves Outcome After Liver Transplantation

The haemodynamic effects of adjunctive hormone therapy in potential heart donors: a prospective randomized double-blind factorially designed controlled trial


May 7, 2014

Complex penetrating duodenal injuries: Less is better

Pyloric Exclusion in the Treatment of Severe Duodenal Injuries: Results from the National Trauma Data Bank


April 23, 2014

Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with signifi cant haemorrhage (CRASH-2): a randomised, placebo-controlled trial

Results of the CONTROL Trial: Efficacy and Safety of Recombinant Activated Factor VII in the Management of Refractory Traumatic Hemorrhage


April 9, 2014

Albumin Replacement in Patients with Severe Sepsis or Septic Shock

High versus Low Blood-Pressure Target in Patients with Septic Shock

A Randomized Trial of Protocol-Based Care for Early Septic Shock


April 2, 2014

High versus Low Blood-Pressure Target in Patients with Septic Shock


March 19, 2014

Acquiring Procedural Skills in ICUs: A Prospective Multicenter Study

Prehospital Use of Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Is Associated With a Reduced Incidence of Trauma-Induced Coagulopathy

Sternotomy or Drainage for a Hemopericardium After Penetrating Trauma


March 12, 2014

Co-administration of furosemide with albumin for overcoming diuretic resistance in patients with hypoalbuminemia: A meta-analysis

Albumin and furosemide therapy in hypoproteinemic patients with acute lung injury

Diuretic Strategies in Patients with Acute Decompensated Heart Failure


March 5, 2014

Transfusion Strategies for Acute Upper Gastrointestinal Bleeding

A Multicenter, Randomized, Controlled Clinical Trial OF Transfusion Requirements IN Critical Care

The CRIT Study: Anemia and blood transfusion in the critically ill—Current clinical practice in the United States


Feb. 26, 2014

Use of procalcitonin to reduce patients’ exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial

A Randomized Controlled Trial of an Antibiotic Discontinuation Policy for Clinically Suspected Ventilator-Associated Pneumonia


Feb. 19, 2014

Management of pelvic ring fracture patients with a pelvic ‘‘blush’’ on early computed tomography

Outcomes of adding acute care nurse practitioners to a Level I trauma service with the goal of decreased length of stay and improved physician and nursing satisfaction

The persistent diagnostic challenge of thoracoabdominal stab wounds


Feb. 5, 2014

Lack of difference among terlipressin, somatostatin, and octreotide in the control of acute gastroesophageal variceal hemorrhage

Chlorhexidine–Alcohol versus Povidone– Iodine for Surgical-Site Antisepsis

Early Use of TIPS in Patients with Cirrhosis and Variceal Bleeding


Jan. 22, 2014

The International Normalized Ratio overestimates coagulopathy in stable trauma and surgical patients

Activity of factor VII in patients with isolated blunt traumatic brain injury: Association with coagulopathy and progressive hemorrhagic injury

The effects of tranexamic acid and prothrombin complex concentrate on the coagulopathy of trauma: An in vitro analysis of the impact of severe acidosis


Jan. 15, 2014

Effect Of Prone Positioning on the Survival of Patients with Acute Respiratory Failure

Prone Positioning in Patients With Moderate and Severe Acute Respiratory Distress Syndrome

Prone Positioning in Severe Acute Respiratory Distress Syndrome


Jan. 8, 2014

The effect of epidural placement in patients after blunt thoracic trauma

Epidural analgesia improves outcome after multiple rib fractures

A multidisciplinary clinical pathway decreases rib fracture–associated infectious morbidity and mortality in high-risk trauma patients


Dec. 11, 2013

Prospective evaluation of the utility of routine postoperative cystogram after traumatic bladder injury

Diagnostic laparoscopy after anterior abdominal stab wounds: Worth another look?

Western Trauma Association Critical Decisions in Trauma: Penetrating neck trauma


Dec. 4, 2013

Effects of Clinical Supervision on Resident Learning and Patient Care During Simulated ICU Scenarios

NEXUS Chest Validation of a Decision Instrument for Selective Chest Imaging in Blunt Trauma

The Frequency and Cost of Treatment Perceived to Be Futile in Critical Care


Nov. 20, 2013

Computed Tomographic Pulmonary Angiography vs Ventilation-Perfusion Lung Scanning in Patients With Suspected Pulmonary Embolism

Excluding Pulmonary Embolism at the Bedside without Diagnostic Imaging: Management of Patients with Suspected Pulmonary Embolism Presenting to the Emergency Department by Using a Simple Clinical Model and D-Dimer

Gadolinium-Enhanced Magnetic Resonance Angiography for Pulmonary Embolism


Nov. 6, 2013

Splenectomy in patients with traumatic brain injury: Protective or harmful? A National Trauma Data Bank analysis

The impact of liver cirrhosis on outcomes in trauma patients: A prospective study

The swinging pendulum: A national perspective of nonoperative management in severe blunt liver injury


Oct. 23, 2013

Hydrocortisone Therapy for Patients with Septic Shock

Impact of bolus application of low-dose hydrocortisone on glycemic control in septic shock patients

Prescribing Patterns of Hydrocortisone in Septic Shock: A Single-Center Experience of How Surviving Sepsis Guidelines Are Interpreted and Translated into Bedside Practice


Oct. 16, 2013

Effect of Heart Rate Control With Esmolol on Hemodynamic and Clinical Outcomes in Patients With Septic Shock

Effects of Fluid Resuscitation With Colloids vs Crystalloids on Mortality in Critically Ill Patients Presenting With Hypovolemic Shock

Long-Term Cognitive Impairment after Critical Illness


Oct. 9, 2013

Noninvasive Positive-Pressure Ventilation for Respiratory Failure after Extubation

Non-invasive ventilation after extubation in hypercapnic patients with chronic respiratory disorders: randomised controlled trial

  NONINVASIVE VENTILATION FOR ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema


Oct. 2, 2013

Family Presence during Cardiopulmonary Resuscitation

Flexible Esophagoscopy as a Diagnostic Tool for Traumatic Esophageal Injuries

Presentations and outcomes in patients with traumatic diaphragmatic injury: A 15-year experience


Sept. 18, 2013

Effect of video laryngoscopy on trauma patient survival: A randomized controlled trial

A, B, C, D, echo: Limited transthoracic echocardiogram is a useful tool to guide therapy for hypotension in the trauma bayVA pilot study

Risk Factors for 24-Hour Mortality After Traumatic Rib Fractures Owing to Motor Vehicle Accidents: A Nationwide Population-Based Study


Sept. 11, 2013

A Randomized Prospective Trial of Airway Pressure Release Ventilation and Low Tidal Volume Ventilation in Adult Trauma Patients With Acute Respiratory Failure

Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome

Sternal fracture: Isolated lesion versus polytrauma from associated extrasternal injuriesVAnalysis of 1,867 cases


Sept. 4, 2013

Potential effect of physiotherapeutic treatment on mortality rate in patients with severe sepsis and septic shock: A retrospective cohort analysis

Whole-body computed tomography is associated with decreased mortality in blunt trauma patients with moderate-to-severe consciousness disturbance: A multicenter, retrospective study


Aug. 21, 2013

A Trial of Intraoperative Low-Tidal-Volume Ventilation in Abdominal Surgery

Oral Apixaban for the Treatment of Acute Venous Thromboembolism

Riociguat for the Treatment of Pulmonary Arterial Hypertension


Aug. 14, 2013

A Comparison of Albumin and Saline for Fluid Resuscitation in the Intensive Care Unit

Value of Repeat Head Computed Tomography after Traumatic Brain Injury: Systematic Review and Meta-Analysis

Vasopressin, Steroids, and Epinephrine and Neurologically Favorable Survival After In-Hospital Cardiac Arrest - A Randomized Clinical Trial


Aug. 7, 2013

Daily Interruption of Sedative Infusions in Critically Ill Patients Undergoing Mechanical Ventilation

Daily Sedation Interruption in Mechanically Ventilated Critically Ill Patients Cared for With a Sedation Protocol

Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial


July 31, 2013

Risk of venous thromboembolism associated with peripherally inserted central catheters: a systematic review and meta-analysis


July 25, 2013

Does the Central Venous Pressure Predict Fluid Responsiveness? An Updated Meta-Analysis and a Plea for Some Common Sense

Routine Follow-Up Imaging of Kidney Injuries May Not Be Justified

Oral midodrine treatment accelerates the liberation of intensive care unit patients from intravenous vasopressor infusions


July 17, 2013

Targeted versus Universal Decolonization to Prevent ICU Infection

A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial

Evaluation of Immediate Endoscopic Realignment as a Treatment Modality for Traumatic Urethral Injuries


July 10, 2013

Diluting the benefits of hemostatic resuscitation: A multi-institutional analysis

Transfusion of red blood cells in patients with a prehospital Glasgow Coma Scale score of 8 or less and no evidence of shock is associated with worse outcomes

Uncontrolled hemorrhagic shock results in a hypercoagulable state modulated by initial fluid resuscitation regimens


July 3, 2013

Early resuscitation intensity as a surrogate for bleeding severity and early mortality in the PROMMTT study

Prehospital intravenous fluid is associated with increased survival in trauma patients


June 26, 2013

Not so fast to skin graft: Transabdominal wall traction closes most ‘‘domain loss’’ abdomens in the acute setting

Prevention of surgical site infections in high-risk patients with laparotomy incisions using negative-pressure therapy


June 19, 2013

Patients with traumatic subarachnoid hemorrhage are at low risk for deterioration or neurosurgical intervention

Prevention of surgical site infections in high-risk patients with laparotomy incisions using negative-pressure therapy


June 12, 2013

A standardized rapid sequence intubation protocol facilitates airway management in critically injured patients

The ‘‘found down’’ patient: A diagnostic dilemma

Intensive care unit bounce back in trauma patients: An analysis of unplanned returns to the intensive care unit


May 29, 2013

An Emergency Department Thawed Plasma Protocol for Severely Injured Patients

Complications arising from splenic artery embolization: a review of an 11-year experience

Diagnosing blunt hollow viscus injury: is computed tomography the answer?


May 23, 2013

A 5-year Clinical Experience with Single-Staged Repairs of Infected and Contaminated Abdominal Wall Defects Utilizing Biologic Mesh


May 22, 2013

Comparing clinical predictors of deep venous thrombosis versus pulmonary embolus after severe injury: A new paradigm for posttraumatic venous thromboembolism?

Prospective, Randomized Assessment of Transfer of Training (ToT) and Transfer Effectiveness Ratio (TER) of Virtual Reality Simulation Training for Laparoscopic Skill Acquisition


May 21, 2013

A 5-year Clinical Experience with Single-Staged Repairs of Infected and Contaminated Abdominal Wall Defects Utilizing Biologic Mesh


May 15, 2013

A principal component analysis of coagulation after trauma

Aggressive early crystalloid resuscitation adversely affects outcomes in adult blunt trauma patients: An analysis of the Glue Grant database

How Much Free Fluid Can a Pregnant Patient Have? Assessment of Pelvic Free Fluid in Pregnant Patients Without Antecedent Trauma


May 8, 2013

Life after near death: Long-term outcomes of emergency department thoracotomy survivors

Oral Antibiotic Bowel Preparation Reduces Length of Stay and Readmissions after Colorectal Surgery

Stapled Versus Hand-Sewn Anastomoses in Emergency General


May 1, 2013

Prospective Randomized Controlled Trial of Operative Rib Fixation in Traumatic Flail Chest

Serum Procalcitonin for Predicting the Failure of Conservative Management and the Need for Bowel Resection in Patients with Small Bowel Obstruction
 
Subglottic secretion drainage for preventing ventilator associated pneumonia A meta analysis


April 24, 2013

Which central venous catheters have the highest rate of catheter-associated deep venous thrombosis: A prospective analysis of 2,128 catheter days in the surgical intensive care unit

Lactate clearance as a predictor of mortality in trauma patients


April 16, 2013

A prospective multicenter comparison of levetiracetam versus phenytoin for early posttraumatic seizure prophylaxis

Are Commercial Negative Pressure Systems Worth the Cost in Open Abdomen Management?

Proportional Costs in Trauma and Acute Care Surgery Patients: Dominant Role of Intensive Care Unit Costs  


April 10, 2013

Functional outcomes following blunt cerebrovascular injury


April 4, 2013

Oral Antibiotic Bowel Preparation Reduces Length of Stay and Readmissions after Colorectal Surgery

Repeat head computed tomography after minimal brain injury identifies the need for craniotomy in the absence of neurologic change


April 3, 2013

Fifteen-Year Trauma System Performance Analysis Demonstrates Optimal Coverage for Most Severely Injured Patients and Identifies a Vulnerable Population

Probiotics in the critically ill: A systematic review of the randomized trial evidence

Early Antibiotic Discontinuation in Patients With Clinically Suspected Ventilator-Associated Pneumonia and Negative Quantitative Bronchoscopy Cultures


March 27, 2013

A population-based analysis of the clinical course of 10,304 patients with acute cholecystitis, discharged without cholecystectomy

An Aspirin a Day Keeps the Acute Respiratory Distress Syndrome Away


March 20, 2013

The Delayed Versus Early Enoxaparin Prophylaxis I (DEEP I) study

TEG-guided resuscitation is superior to standardized MTP resuscitation in massively transfused penetrating trauma patients

The effects of location and low-molecular-weight heparin administration on deep vein thrombosis outcomes in trauma patients


March 13, 2013

Chasing 100 Percent - The use of hypertonic saline to improve early, primary fascial closure after damage control laparotomy

Quality of Life after Abdominal Wall Reconstruction Following Open Abdomen

Open Abdomen


March 6, 2013

Initial inferior vena cava diameter on computed tomographic scan independently predicts mortality in severely injured trauma patients

Microcirculatory Alterations in Patients With Severe Sepsis-Impact of Time of Assessment and Relationship With Outcome

Defining when to initiate massive transfusion-transfusion triggers -PROMMTT


Feb. 13, 2013

Antibiotic Choice Is Independently Associated with Risk of Surgical Site Infection After Colectomy

Impact of Fibrinogen Levels on Outcomes

National Trauma Institute Prospective Evaluation

Surviving Sepsis 2012

Bicarbonate Therapy in Severly Acidotic Trauma Patients Increases Mortality  


July 20, 2011

Ultrasound in central lines and TPN

Real time ultrasound guided subclavian vein cannulation versus the land mark method in critical care patients

Early versus late parenteral nutrition in critically ill adults


July 13, 2011

Lung ventilation volume

Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and ARDS

effect of lung protective ventilation on organ donors - mascia - jama 2010 (2)


June 15, 2011

IVC filter and albumin in sepsis

Prophylactic IVCF may increase Risk of DVT after SCI

Role of Albumin in Sepsis Meta-analysis


June 8, 2011

Albumin, hetastarch and trauma coagulopathy

Albumin in resuscitation

Endogenous and Acquired Coagulopathy

Hetastarch for initial fluid resuscitation


April 20, 2011

Guidelines for decompressive craniectomy in DAI, TF, and SVO2

Decompressive Craniectomy in Diffuse TBI

Initial Trophic vs Full-energy Enteral Nutrition in Vent Pts with Acute Resp Failure

ScvO2 as Marker to define Fluid Responsiveness


March 23, 2011

Antibiotics for open fractures: EAST Guidelines

EAST Update Guidelines for Prophylactic Abx in Open Fractures


March 16, 2011

Hypotensive resuscitation and alternative pressors

Comparison of Norepinephrine-Dobutamine to Epinephrine in cardiogenic shock

Hypotensive Resuscitation Strategy Reduces Transfusion and Coagulopathy


Feb. 16, 2011

Updates on clearing the cervical spine and transfusion requirements

CT Alone may clear the cervical spine in obtunded blunt trauma patients

Transfusion Requirements After Cardiac Surgery


Feb. 9, 2011

Chest tube management in trauma

Impact of positive pressure ventillation on thoracostomy tube removal

Incidence and management of occult hemothoraces

Use of presumptive antibiotics following tube thoracostomy for traumatic hemopneumothorax in the prevention of empyeman and pneumonia


Feb. 2, 2011

Peep in the ICU

APACHE IV Hospital Mortality Assessment for Todays Critically Ill Patients

PEEP Setting in Adults with ALI and ARDS

Recognition and Prevention of Nosocomial Vascular Device and Related Bloodstream Infections in the Intensive Care Unit


Dec. 29, 2010

Epogen after TBI

Improved survival of critically ill trauma patients treated with recombinant human erythropoietin


Dec. 22, 2010

Spine consultation after trauma

Erythropoiesis stimulating agent administration improves survival after severe TBI

Is spine consultation needed for all thoracolumbar fractures


Dec. 1, 2010

Hypertonic Saline after TBI

Out of hospital Hypertonic Resuscitation following severe TBI


Nov. 10, 2010

VAP and paralysis

Duration of Hypotension before Initiation of Effective Abx is Critical Determinant of Survival in Septic Shock

Measurable Outcomes of Quality Improvement Using a Daily Quality Rounds Checklist-VAP Reduction

Neuromuscular Blockers in Early ARDS


Oct. 27, 2010

Tranexamic Acid and Factor 7 in Trauma

Effects of Tranexamic Acid in Trauma Pts (CRASH-2)

Results of the CONTROL Trial Efficacy & Safety of rFVIIa in Traumatic Hemorrhage


Oct. 13, 2010

Management of TBI patients

  Early Tracheostomy versus Prolonged Endotracheal Intubation in Severe Head Injury

Management of TBI Patients by EBM Protocol Improves Outcomes

Reduced Mortality in Patients with Severe TBI Treated with Brain Tissue Oxygen Monitoring


Aug. 16, 2010

Mortality related to rib fractures

Half-a-dozen ribs: The breakpoint for mortality

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