The Khan Laboratory focuses on the discovery and characterization of novel mechanisms that regulate myeloid cell immune response and developing ways that augment and enhance these responses. The lab aims to develop gene- or cell-based therapy to boost the myeloid cell response against a variety of immune challenges. A special interest of the lab is to develop human stem cell-engineered super myeloid cells for immunotherapy to treat aggressive infections and cancer.
The Khan Laboratory is affiliated with the Cedars-Sinai Department of Pathology and Laboratory Medicine; Department of Biomedical Sciences; and Samuel Oschin Comprehensive Cancer Institute.
My current research interests involve studying new mechanisms that regulate myeloid cell immunity. A particular focus area is understanding the role of renin-angiotensin system (RAS) in the function of myeloid-derived cells, with emphasis on the role of angiotensin-converting enzyme (ACE1 and ACE2) in homeostasis and immune responses of macrophages and neutrophils to infections, tumors and chronic illnesses like atherosclerosis and Alzheimer’s disease.
Zakir Khan, PhD
- Myeloid Cell Immune Response
- Stem Cell-Engineered Immune Cell Therapy
- Viral-Vector Gene Therapy
- Experimental Cancer Therapeutics
- Neuroimmunology and Neurorepair
- Xiaojiang Cui, PhD
- Warren Tourtellotte, MD, PhD
- Stephen Shiao, MD, PhD
- Allen Ho, MD
- Eric Veil
- Kenneth Bernstein, MD
- Helen Goodridge, PhD
- Jorge Giani, PhD
- Immunology and Immunotherapy Research
- Samuel Oschin Comprehensive Cancer Institute
- Department of Pathology and Laboratory Medicine
- Department of Biomedical Sciences
- Dr. George Y. Liu (UC San Diego School of Medicine)
Meet Our Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Khan Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Shibata T, Cao DY, Dar TB, Ahmed F, Bhat SA, Veiras LC, Bernstein EA, Khan AA, Chaum M, Shiao SL, Tourtellotte WG, Giani JF, Bernstein KE, Cui X, Vail E, Khan Z.
Cancers (Basel). 2022 Oct 27;14(21):5273.
Cao DY, Giani JF, Veiras LC, Bernstein EA, Okwan-Duodu D, Ahmed F, Bresee C, Tourtellotte WG, Karumanchi SA, Bernstein KE, Khan Z.
Sci Transl Med. 2021 Jul 28;13(604):eabj2138
Khan Z, Terrien E, Delhommel F, Lefebvre-Omar C, Bohl D, Vitry S, Bernard C, Ramirez J, Chaffotte A, Ricquier K, Vincentelli R, Buc H, Prehaud C, Wolff N, Lafon M.
J Biol Chem. 2019 Sep 13;294(37):13755-13768.
Khan Z, Shen XZ, Bernstein EA, Giani JF, Eriguchi M, Zhao TV, Gonzalez-Villalobos RA, Fuchs S, Liu GY, Bernstein KE.
Blood. 2017 Jul 20;130(3):328-339.
Contact the Khan Lab
8700 Beverly Blvd.
Davis Building, Room D5068
Los Angeles, CA 90048