Founded in 2011 and directed by diabetes research pioneer Richard N. Bergman, PhD, the Cedars-Sinai Diabetes and Obesity Research Institute joins the discoveries of the laboratory with the real-world utilization of the clinic to delve into comprehensive investigation of the mechanisms at work in both diseases — with an eye toward the discovery and implementation of truly novel and effective treatment options.
Partnering with Cedars-Sinai's team of passionate researchers and clinicians is Sports Spectacular, a philanthropic organization focused on building a healthier world for all. As part of their commitment to combatting diabetes and obesity, and the powerful effect they have on the health of the community, Sports Spectacular has pledged $10 million to form the Sports Spectacular Diabetes and Obesity Wellness and Research Center within the Institute. The Center will focus on medical research, as well as developing effective ways to get children and adults eating better and exercising more.
- Examine relationships between obesity, insulin resistance and diabetes
- Identify compounds or procedures that can reduce obesity, or can suppress the linkage between obesity and insulin resistance, and insulin resistance and Type 2 diabetes
- Study the mechanisms of underlying beta-cell failure, and how failure of the pancreatic beta-cells interact with insulin resistance to cause diabetes
- Test therapies for diabetes, including implanted devices to treat the disease, and regenerative medicine approaches to compensate for reduced beta-cell function
- Investigate the importance of the gut-brain axis in glucose regulation, particularly with regard to the gut hormone GLP-1, as well as how signals in the abdominal portal vein are detected by specific sensors and the role of those sensors in carbohydrate metabolism