Instrumentation

Multiple biomedical imaging systems are available at the Imaging Core. The core provides experienced technologists for the acquisition and basic image processing, as well as for administration of anesthesia (small animals), contrast agents and PET tracers. Please refer to iLab for our imaging rates.

Contact Grant Dagliyan at grant.dagliyan@cshs.org if you have questions or need assistance.

Siemens MAGNETOM Vida 3T MRI

  • Human and large animal imaging
  • First MRI scanner with BioMatrix Technology, allowing for consistent, high-quality personalized exams with less scan failure.
  • GPU-accelerated inline compressed sensing for cardiac cine imaging
  • Free-breathing dynamic liver exams powered by compressed sensing GRASP-VIBE
  • Reliable and distortion-free whole-body DWI scans enabled by novel SliceAdjust and CoilShim technologies
  • Simultaneous Multi-Slice (SMS) significantly reduces acquisition time for brain and abdominal diffusion imaging
  • MR elastography and LiverLab package for quantitative liver assessment
  • Brain functional MRI with task presentation systems
  • Diffusion imaging: ADC mapping, fiber tracking
  • Angiography: non-contrast or contrast-enhanced
  • Vascular imaging: angiography, vessel wall imaging
  • Cardiac imaging: perfusion, diffusion, function, late-enhancement, T1/T2 mapping
  • Body imaging: spine, cancer characterization, respiratory motion characterization
  • Molecular imaging: cell tracking, targeted enhancement


Siemens Biograph mMR MR-PET

  • Human and large animal imaging
  • True simultaneous MR and PET whole body acquisition resulting in improved co-registration of PET and MRI images, shorter overall imaging times and ability to observe rapidly changing physiological processes simultaneously
  • Available for research and clinical (standard-of-care) use
  • 3T MRI similar to Verio system (see above)
  • Functional MRI task presentation system
  • Multinuclear MR spectroscopy available


Bruker BioSpin 9.4T micro-MRI

  • Small animal imaging
  • 1H, 15N, 13C and X nuclei imaging and spectroscopy for in vivo and molecular MRI applications
  • Proton spectroscopy, single voxel, 2D and 3D capabilities
  • Metabolic composition and fat analysis
  • Diffusion imaging with fiber tracking capability
  • Angiography
  • Relaxation time measurements and analysis (T1 and T2)
  • Stroke detection, e.g., cerebral blood flow, diffusion tensor imaging
  • Cardiac imaging and function measurement
  • Tumor imaging
  • Longitudinal size analysis


Scanco vivaCT40 micro-CT

  • Small animal in vivo and specimens
  • Outstanding high resolution CT (10 µm)
  • Respiratory gating
  • 3D morphology of cartilage and bone
  • Analysis of visceral and subcutaneous adiposity
  • Imaging of tissue engineering scaffold
  • Hierarchical micro imaging for multi-scale analysis of large vascular networks
  • 3D evaluation of the trabecular and cortical structure
  • Bone volume measurement
  • Quantitative imaging of lung tumors


IVIS® Spectrum Optical Imaging System

  • Whole-body in vivo for small animals
  • High resolution fluorescence and bioluminescence
  • Multiple labels
  • Relative quantitative analysis
  • Full spectral tunability
  • Epi-illumination
  • Trans-illumination
  • Longitudinal analysis and quantification
  • Absolute calibration
  • Multimodal co-registration (PET, CT, MRI)
  • Spectral unmixing
  • Optimal applications: Oncology imaging, stem cell tracking and analysis, drug delivery, cardiovascular diseases, angiogenesis, infection disease, inflammation, pulmonary


IVIS® Lumina XR Optical Imaging System

  • Whole-body in vivo for small animals
  • High resolution fluorescence and bioluminescence with precise x-ray overlay option
  • Multiple labels
  • Relative quantitative analysis
  • Full spectral tunability
  • Epi-illumination
  • Trans-illumination
  • Longitudinal analysis and quantification
  • Absolute calibration
  • Multimodal co-registration (PET, CT, MRI)
  • Spectral unmixing
  • Optimal applications: Oncology imaging, stem cell tracking and analysis, drug delivery, cardiovascular diseases, angiogenesis, infection disease, inflammation, pulmonary


CRi Maestro Fluorescence

  • High resolution fluorescence
  • Multiple labels
  • Relative quantitative analysis
  • Applications: Fluorescent tumor models, antibody based assays, molecular targeting agents, fluorescent drug pharmacokinetics, angiogenesis markers

 



Precision X-Ray X-RAD SmART

  • A small animal image guided irradiation system with a fully integrated bioluminescence imaging platflorm
  • Image guided targeting precision up to 0.1mm
  • Fully automated registration with CT
  • Precise tumor localization for non-palpable tumors
  • Combines Monte Carlo calculation algorithms to rapidly devise treatment plans
  • Gold standard accuracy for static beams, arcs, and non-coplanar treatments across single and multiple isocenters
  • Measure tumor viability

Notting Hill Devices Preclinical Scanner (4Dx)

  • A small animal preclinical scanner
  • Four-dimensional CT scanner designed for measuring respiratory function and health
  • High levels of sensitivity
  • Offers extremely high-resolution and high-sensitivity scanning
  • Can be used as an X-ray device, 3D CT scanner and a 4D CT scanner
  • Raw data is analyzed with pioneering 4Dx lung imaging software