Publications

See a complete PubMed list of publications by Joshua Goldhaber, MD.

Selected Key Publications

Cho JH, Kilfoil PJ, Zhang R, Solymani RE, Bresee C, Kang EM, Luther K, Rogers RG, de Couto G, Goldhaber JI, et al. Reverse electrical remodeling in rats with heart failure and preserved ejection fraction. JCI. Insight. 2018 Oct 4;3(19). pii: 121123. https://insight.jci.org/articles/view/121123.

Bögeholz N, Pauls P, Dechering DG, Frommeyer G, Goldhaber JI, Pott C, Eckardt  L, Müller FU, Schulte JS. Distinct occurrence of proarrhythmic after depolarizations in atrial versus ventricular cardiomyocytes: implications for translational research on atrial arrhythmia. Front Pharmacol. 2018 Aug 21;9:933. https://www.frontiersin.org/articles/10.3389/fphar.2018.00933/full.

Cho JH, Zhang R, Aynaszyan S, Holm K, Goldhaber JI, Marbán E, Cingolani E. Ventricular arrhythmias underlie sudden death in rats with heart failure and preserved ejection fraction. Circ Arrhythm Electrophysiol. 2018 Aug;11(8):e006452. https://www.ahajournals.org/doi/full/10.1161/CIRCEP.118.006452.

John S, Kim B, Olcese R, Goldhaber JI, Ottolia M. Molecular determinants of pH regulation in the cardiac Na+-Ca2+ exchanger. J Gen Physiol. 2018 Feb 5;150(2):245-257. http://jgp.rupress.org/content/150/2/245.

Cingolani E, Goldhaber JI, Marbán E. Next-generation pacemakers: from small devices to biological pacemakers. Nat Rev Cardiol. 2018 Mar;15(3):139-150. https://www.nature.com/articles/nrcardio.2017.165.

Bögeholz N, Schulte JS, Kaese S, Bauer BK, Pauls P, Dechering DG, Frommeyer G, Goldhaber JI, Kirchhefer U, Eckardt L, et al. The effects of SEA0400 on Ca2+ transient amplitude and proarrhythmia depend on the Na+/Ca2+ exchanger expression level in murine models. Front Pharmacol. 2017 Sep 21;8:649. https://www.frontiersin.org/articles/10.3389/fphar.2017.00649/full.

Cho JH, Zhang R, Kilfoil PJ, Gallet R, de Couto G, Bresee C, Goldhaber JI, Marbán E, Cingolani E. Delayed repolarization underlies ventricular arrhythmias in rats with heart failure and preserved ejection fraction. Circulation. 2017 Nov 21;136(21):2037-2050. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.028202.

Yue X, Zhang R, Kim B, Ma A, Philipson KD, Goldhaber JI. Heterogeneity of transverse-axial tubule system in mouse atria: remodeling in atrial-specific Na+-Ca2+ exchanger knockout mice. J Mol Cell Cardiol. 2017 Jul;108:50-60. https://www.sciencedirect.com/science/article/pii/S0022282817301050.

Torrente AG, Zhang R, Wang H, Zaini A, Kim B, Yue X, Philipson KD, Goldhaber JI. Contribution of small conductance K+ channels to sinoatrial node pacemaker activity: insights from atrial-specific Na+/Ca2+ exchange knockout mice. J Physiol. 2017 Jun 15;595(12):3847-3865. https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/JP274249.

Kapoor N, Tran A, Kang J, Zhang R, Philipson KD, Goldhaber JI. Regulation of calcium clock-mediated pacemaking by inositol-1,4,5-trisphosphate receptors in mouse sinoatrial nodal cells. J Physiol. 2015 Jun 15;593(12):2649-2663. http://onlinelibrary.wiley.com/doi/10.1113/JP270082/abstract.

Torrente AG, Zhang R, Zaini A, Giani JF, Kang J, Lamp ST, Philipson KD, Goldhaber JI. Burst pacemaker activity of the sinoatrial node in sodium-calcium exchanger knockout mice. Proc Natl Acad Sci USA. 2015;112(31):9769-9774. http://www.pnas.org/content/112/31/9769.

Bögeholz N, Pauls P, Bauer BK, Schulte JS, Dechering DG, Frommeyer G, Kirchhefer U, Goldhaber JI, Müller FU, Eckardt L, Pott C. Suppression of early and late afterdepolarizations by heterozygous knockout of the Na+/Ca2+ exchanger in a murine model. Circ Arrhythm Electrophysiol. 2015;8(5):1210-1218. http://circep.ahajournals.org/content/8/5/1210.

Shimizu H, Schredelseker J, Huang J, Lu K, Naghdi S, Lu F, Franklin S, Fiji HD, Wang K, Zhu H, Tian C, Lin B, Nakano H, Ehrlich A, Nakai J, Stieg AZ, Gimzewski JK, Nakano A, Goldhaber JI, et al. Mitochondrial Ca2+ uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity. Elife. 2015 Jan 15;4. http://elifesciences.org/content/4/e04801.

Torres NS, Sachse FB, Izu LT, Goldhaber JI, Spitzer KW, Bridge JH. A modified local control model for Ca2+ transients in cardiomyocytes: junctional flux is accompanied by release from adjacent non-junctional RyRs. J Mol Cell Cardiol. 2014 Mar;68:1-11. http://www.jmmc-online.com/article/S0022-2828(13)00368-4/abstract.

Myerburg RJ, Halperin H, Egan DA, Boineau R, Chugh SS, Gillis AM, Goldhaber JI, Lathrop DA, Liu P, Niemann JT, et al. Pulseless electrical activity: definition, causes, mechanisms, management, and research priorities for the next decade: report from a National Heart, Lung, and Blood Institute workshop. Circulation. 2013 Dec 3;128(23):2532-2541. http://circ.ahajournals.org/content/128/23/2532.