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The Freeman Laboratory focuses on urogenital tract physiology, with a primary focus on cancer progression from onset to lethal disease. Prostate cancer is an area of strong emphasis. We also have an interest and substantial publication history in bladder cancer, breast cancer, smooth muscle regulation and dysfunction, and interstitial cystitis/pelvic pain syndrome.
Specific areas of study include:
- Lipid metabolism and points of intersection of metabolic pathways with oncogenic signal transduction mechanisms
- The role of circulating cholesterol in prostate cancer cell growth and survival and opportunities for inhibition of disease progression using cholesterol targeting strategies
- Tumor cell plasticity, particularly the origin and significance of the poorly understood amoeboid tumor cell phenotype
- Chromatin structure in relation to androgen receptor function, lipid metabolism and metabolic pathways
- The role of bioactive extracellular vesicles ("oncosomes") produced by tumor cells and the profiling of these particles for the purpose of developing biomarker signatures that report tumor characteristics and response to therapy
- Quantitative mass spectrometry-based proteomics as a means of studying signal transduction and biomarker discovery.